A ground-glass opacity is a hazy gray area on a CT scan of the lungs, through which the blood vessels and airways can still be seen, like looking through frosted glass. It is a description, not a diagnosis: it can come from infection, inflammation, fluid, early scarring or, when it persists as a nodule, an early form of lung adenocarcinoma.
Origin
The term comes from radiology and was standardized in the Fleischner Society's glossary of chest-imaging terms. It came into wide use with high-resolution CT in the 1980s and 1990s, and later with CT lung cancer screening.
Significance in Asbestos Context
Ground-glass changes appear in asbestos-related reports in two different ways. Diffuse or patchy ground-glass areas near the lung surface can be seen in early interstitial lung disease, including some cases of asbestosis, though asbestosis is more typically described by lines, bands and, later, honeycombing in the lower lungs; many other causes, such as infection or drug reactions, produce the same picture. A ground-glass or part-solid nodule that persists for months is a different matter: it can be an early lung adenocarcinoma, which is often slow-growing, and is usually followed with repeat CT scans and sometimes biopsied. For a claim, a radiologist's mention of ground-glass opacity is not by itself evidence of asbestosis or of cancer; the significance depends on the pattern, its location, whether it persists, and the rest of the medical picture. A pulmonologist or B-reader can explain what a particular finding means.
Example Sentence
The CT showed a persistent 12-millimeter ground-glass nodule in the right upper lobe, and his doctors recommended a follow-up scan in three months.
Related Terms
High-Resolution CT (HRCT), CT Scan, Interstitial Lung Disease, Asbestosis, Lung Adenocarcinoma, Subpleural Curvilinear Line, Lung-RADS
Notes
- Ask whether a ground-glass finding is diffuse or a single nodule, and what follow-up is recommended.
- Ground-glass changes from an infection often clear; a repeat scan may be needed to tell.
- Keep follow-up appointments for any persistent nodule, even a small one.
In the research library
5 studies in our medical research library mention Ground-Glass Opacity in the title or abstract. Among the most cited:
- Asbestos-related pleuropulmonary diseases: evaluation with low-dose four-detector row spiral CTM. Remy-Jardin, A. Sobaszek, A. Duhamel, et al, 2004 · Radiology · cited 45 times
- Minute localized malignant pleural mesothelioma coexisting with multiple adenocarcinomasR. Maeda, N. Isowa, H. Onuma, et al, 2010 · General Thoracic and Cardiovascular Surgery · cited 9 times
- The effects of secondhand smoke exposure on HRCT findings among asbestos-exposed workersT. Vierikko, R. Järvenpää, J. Uitti, et al, 2008 · Respiratory Medicine · cited 7 times
- Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literatureW. RanYue, W. ChunYan, H. Likun, et al, 2023 · Diagnostic Pathology · cited 4 times
- Pulmonary asbestosis: radiologic-pathologic brief reportC.S. Ahn, S.J. Kim, S.J. Oh, et al, 1997 · Yonsei Medical Journal · cited 4 times
The journals that publish most on it: Radiology (1), Respiratory Medicine (1), Diagnostic Pathology (1).
Category: Diagnostic Tools & Biomarkers · All Lexicon terms A–Z
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