Honeycombing describes a pattern, seen on chest CT scans or in lung tissue, where destroyed and scarred lung takes on clustered small cystic air spaces with thick walls, resembling a honeycomb. It is a sign of advanced, irreversible lung scarring (fibrosis). In asbestos disease it can appear in the later stages of asbestosis.
Origin
The term comes from the visual resemblance to the hexagonal cells of a beehive's honeycomb. It has been used in radiology and pathology since the mid-twentieth century to describe end-stage fibrotic lung.
Significance in Asbestos Context
For a patient, honeycombing on a CT scan signals that lung scarring has reached an advanced, permanent stage, which affects breathing capacity, prognosis, and treatment options. When it appears alongside a history of asbestos exposure and findings like pleural plaques, it supports a diagnosis of asbestosis rather than another cause of fibrosis. Because honeycombing also occurs in other diseases such as idiopathic pulmonary fibrosis, your doctors weigh the whole picture, including your exposure history, the distribution of scarring, and pleural changes. The imaging report describing honeycombing can be important documentation for a claim.
Example Sentence
The radiologist noted subpleural honeycombing in both lower lung zones, consistent with the patient's long history of asbestos exposure.
Related Terms
Asbestosis, Pulmonary Fibrosis, Pleural Plaques, High-Resolution CT, Interstitial Lung Disease
Notes
- Request copies of your CT scans and the radiologist's reports, which often mention honeycombing specifically.
- Ask whether high-resolution CT (HRCT) was used, as it shows honeycombing best.
- The pattern and location of fibrosis help distinguish asbestosis from other fibrotic diseases.
In the research library
31 studies in our medical research library mention Honeycombing in the title or abstract. Among the most cited:
- Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposureP.A. Gevenois, V. de Maertelaer, A. Madani, et al, 1998 · The European Respiratory Journal · cited 94 times
- Asbestosis: high-resolution CT-pathologic correlationM. Akira, S. Yamamoto, K. Yokoyama, et al, 1990 · Radiology · cited 94 times
- Peribronchiolar metaplasia: a common histologic lesion in diffuse lung disease and a rare cause of interstitial lung disease: clinicopathologic features of 15 casesJ. Fukuoka, T.J. Franks, T.V. Colby, et al, 2005 · The American Journal of Surgical Pathology · cited 81 times
- Crackles (rales) in the interstitial pulmonary diseasesG.R. Epler, C.B. Carrington, E.A. Gaensler, 1978 · Chest · cited 70 times
- Pulmonary fibrosis in aluminum oxide workers. Investigation of nine workers, with pathologic examination and microanalysis in three of themP.J. Jederlinic, J.L. Abraham, A. Churg, et al, 1990 · The American Review of Respiratory Disease · cited 67 times
The journals that publish most on it: Chest (2), European Journal of Radiology (2), Radiology (2).
Category: Clinical Signs & Symptoms · All Lexicon terms A–Z
This page is provided for general informational purposes and does not constitute legal advice. Every asbestos case turns on its own facts, exposure history, diagnosis, deadlines, available evidence, and applicable law. Reviewing this page does not create an attorney-client relationship. For advice about your specific situation, call 833-4-ASBESTOS for a free case review.