A neoplasm is an abnormal growth of tissue caused by cells that divide and grow when they should not. Neoplasms can be benign (not cancerous, do not spread) or malignant (cancerous, able to invade nearby tissue and spread to other parts of the body). The word is often used in pathology reports as a more precise alternative to "tumor."
Origin
From the Greek neo (new) and plasma (formation or growth). The term entered medical use in the 19th century as pathologists, especially Rudolf Virchow, developed cellular theories of disease and needed a precise word for newly formed abnormal tissue.
Significance in Asbestos Context
Most asbestos-related cancers (including pleural and peritoneal mesothelioma, lung cancer, laryngeal cancer, and ovarian cancer) are described in pathology reports as malignant neoplasms. The exact wording used by the pathologist matters: terms like "malignant neoplasm of the pleura" or "malignant mesothelial neoplasm" appear in records that your medical and legal teams will rely on to confirm diagnosis, stage the disease, and link it to asbestos exposure. Benign asbestos-related findings (such as pleural plaques) are not neoplasms, and distinguishing benign from malignant findings is central to both your treatment plan and any claim.
Example Sentence
The biopsy report described a "malignant neoplasm of mesothelial origin," which the oncologist explained meant pleural mesothelioma caused by his decades of asbestos exposure as a pipefitter.
Related Terms
Mesothelioma, Malignancy, Tumor, Carcinoma, Pathology Report, Biopsy
Notes
- Request a full copy of every pathology report; the exact diagnostic wording ("malignant neoplasm," cell type, immunohistochemistry results) will be needed by both your treating physicians and your legal team.
- Ask your doctor to clarify whether any finding labeled a "neoplasm" is benign or malignant. The distinction changes treatment, prognosis, and claim eligibility.
- If a report uses uncertain language like "neoplasm of uncertain behavior," ask whether additional testing (immunostains, second-opinion review at a mesothelioma specialty center) is recommended before treatment decisions are made.
- Preserve all imaging, biopsy slides, and tissue blocks; these may be needed for expert review if your diagnosis is later contested.
In the research library
820 studies in our medical research library mention Neoplasm in the title or abstract. Among the most cited:
- Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 casesP. Chu, E. Wu, L.M. Weiss, 2000 · Modern Pathology · cited 714 times
- The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms. A comprehensive immunohistochemical study on formalin- and alcohol-fixed tumorsN. Azumi, H. Battifora, 1987 · American Journal of Clinical Pathology · cited 341 times
- Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 casesK. Sheibani, H. Battifora, J.S. Burke, et al, 1986 · The American Journal of Surgical Pathology · cited 190 times
- EWSR1/FUS-CREB fusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavitiesP. Argani, I. Harvey, G.P. Nielsen, et al, 2020 · Modern Pathology · cited 104 times
- Asbestosis and abdominal neoplasmsE.E. Keal, 1960 · Lancet · cited 94 times
The journals that publish most on it: American Journal of Industrial Medicine (22), Curēus (21), The American Journal of Surgical Pathology (20).
Category: Diseases & Conditions · All Lexicon terms A–Z
This page is provided for general informational purposes and does not constitute legal advice. Every asbestos case turns on its own facts, exposure history, diagnosis, deadlines, available evidence, and applicable law. Reviewing this page does not create an attorney-client relationship. For advice about your specific situation, call 833-4-ASBESTOS for a free case review.