Squamous cell carcinoma is a type of cancer that begins in the flat, thin squamous cells that line many surfaces of the body, including the airways of the lungs. In the lungs it's one of the main types of non-small cell lung cancer and is strongly linked to smoking and to asbestos exposure. It often starts in the larger, central airways.
Origin
"Squamous" comes from the Latin squama, meaning scale, describing the flat, scale-like look of these cells under a microscope. "Carcinoma" derives from the Greek karkinos, meaning crab, an ancient term for cancer.
Significance in Asbestos Context
For asbestos patients, squamous cell carcinoma of the lung is one of the cancers that asbestos exposure can cause or contribute to, especially in people who also smoked, since the two exposures multiply the risk. Unlike mesothelioma, lung cancer has other common causes, so proving the asbestos link often relies on exposure history, markers of asbestos disease such as asbestosis or pleural plaques, and expert testimony. A diagnosis backed by evidence of significant asbestos exposure can still support a legal claim even when smoking also played a role.
Example Sentence
My squamous cell carcinoma was blamed on smoking at first, but the pleural plaques on my scans led the doctor to ask about my years insulating boilers.
Related Terms
Non-Small Cell Lung Cancer, Adenocarcinoma, Asbestosis, Pleural Plaques, Synergistic Effect, Lung Cancer
Notes
- Make sure your doctors and legal team know your full asbestos exposure history even if you smoked.
- Ask whether your imaging shows other signs of asbestos disease, such as pleural plaques or asbestosis, which help link the cancer to exposure.
- Smoking doesn't bar an asbestos claim; the combined risk is well recognized, so preserve your work and medical records.
In the research library
231 studies in our medical research library mention Squamous Cell Carcinoma in the title or abstract. Among the most cited:
- Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain TumorsS. Hendry, R. Salgado, T. Gevaert, et al, 2017 · Advances in Anatomic Pathology · cited 657 times
- Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: a case-control study in SwedenP. Gustavsson, R. Jakobsson, H. Johansson, et al, 1998 · Occupational and Environmental Medicine · cited 104 times
- p40 is the best marker for diagnosing pulmonary squamous cell carcinoma: comparison with p63, cytokeratin 5/6, desmocollin-3, and sox2T. Tatsumori, K. Tsuta, K. Masai, et al, 2014 · Applied Immunohistochemistry & Molecular Morphology · cited 52 times
- Next-generation sequencing informs diagnosis and identifies unexpected therapeutic targets in lung squamous cell carcinomasJ.M. Sands, T. Nguyen, P. Shivdasani, et al, 2020 · Lung Cancer · cited 44 times
- MUC4 immunohistochemistry is useful in distinguishing epithelioid mesothelioma from adenocarcinoma and squamous cell carcinoma of the lungA.S. Mawas, V.J. Amatya, K. Kushitani, et al, 2018 · Scientific Reports · cited 26 times
The journals that publish most on it: British Journal of Cancer (7), Occupational and Environmental Medicine (6), Medicine (6).
Category: Diseases & Conditions · All Lexicon terms A–Z
This page is provided for general informational purposes and does not constitute legal advice. Every asbestos case turns on its own facts, exposure history, diagnosis, deadlines, available evidence, and applicable law. Reviewing this page does not create an attorney-client relationship. For advice about your specific situation, call 833-4-ASBESTOS for a free case review.