Adenomatoid tumour of the uterus

Our plain-English summary of Adenomatoid tumour of the uterus, by N. Marcussen, A. Donna (Histopathology, 1988).

The study

• Authors: N. Marcussen, A. Donna
• Journal: Histopathology
• Published: 1988;13(5):582-3
• Type of article: Case report
• Cited by: 5 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

Abstract

Two adenomatoid tumours of the uterus were examined immunohistochemically using antibodies to keratin, Factor VIII related antigen, EMA, CEA and a specific protein isolated from mesothelioma cells. The tumour cells gave positive staining for keratin and for the specific mesothelial marker. The results strongly support a mesothelial origin for adenomatoid tumours and this panel of antibodies may be used to solve diagnostic problems.

In plain English

This brief report described two adenomatoid tumours of the uterus, which the authors called relatively unusual growths. The tumours were found by chance during operations done for other reasons in a 39-year-old and a 47-year-old woman. They measured 1 and 2.5 cm across and lay in the muscle wall of the body of the uterus, just beneath its outer covering. The authors stained the tumours with antibodies to keratin, Factor VIII related antigen, EMA and CEA, and with an antibody against a protein previously found in mesothelioma cells. Neither tumour stained for EMA or CEA. The tumour cells did not stain for Factor VIII, unlike the blood vessels in the same sections. Many tumour cells showed a moderate reaction for keratin, and most, but not all, stained for the mesothelioma protein. The authors concluded that these results indicated the tumours are of mesothelial origin, and that this panel of antibodies may help solve diagnostic problems. The article covers only two cases and does not mention asbestos or any other exposure.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: Brief report: immunohistochemical (antibody staining) study of two tumours
• Who was studied: Two adenomatoid tumours of the uterus, found incidentally at operations done for other purposes, in a 39-year-old and a 47-year-old woman. The tumours were 1 and 2.5 cm in diameter and lay in the myometrium of the corpus, in a sub-serosal location. The article does not say where or when the patients were treated.
• Main results:
  • In both tumours, none of the sections stained for EMA or CEA.
  • The tumour cells did not stain for Factor VIII, unlike the endothelial-lined blood vessels.
  • With antikeratin, many of the tumour cells showed a moderate positive reaction in the cytoplasm.
  • Staining for the specific protein found in mesotheliomas was positive in most, but not all, of the tumour cells.
• The authors' conclusion: The authors concluded that the positive staining for the mesothelial marker indicated that adenomatoid tumours are of mesothelial origin, and that this panel of antibodies may be used to solve diagnostic problems.

Topics

The National Library of Medicine indexes this study under subjects our site covers: Mesothelioma.

Medical terms in this study, explained in our Lexicon: Adenomatoid Tumor, Mesothelioma.

Related studies

• Composite multicystic mesothelioma and adenomatoid tumour of the uterus: different morphological manifestations of the same process? — J.K. Chan, M.H. Fong (1996)
• Adenomatoid tumors of the uterus — J.C. Quigley, W.R. Hart (1981)
• Synchronous occurrence of benign mesothelioma and adenomatoid tumor of uterus: A case report and review of literature — P.R. Shen, J. Cen, et al. (2019)
• The significance of epithelial differentiation in mixed mesodermal tumors of the uterus. A clinicopathologic and immunohistochemical study — P. Bitterman, B. Chun, et al. (1990)
• TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with malignant mesothelioma — H. Itami, T. Fujii, et al. (2021)
• Uterine adenomatoid tumors confirmed by immunohistochemical staining — M. Irikoma, K. Takahashi, et al. (2001)

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