Colonic invasion of malignant peritoneal mesothelioma

Our plain-English summary of Colonic invasion of malignant peritoneal mesothelioma, by C.C. Chan, H. Isomoto, K. Ohnita, et al (Gastrointestinal Endoscopy, 2010).

The study

• Authors: C.C. Chan, H. Isomoto, K. Ohnita, Y. Mizuta, S. Kohno, T. Hayashi
• Journal: Gastrointestinal Endoscopy
• Published: 2010;71(2):397-8; discussion 398
• Type of article: Case report
• Cited by: 1 article, as counted by NIH iCite
• Read it: PubMed · Publisher

In plain English

This was a short image-based case report (a "Focal Point") by doctors at Nagasaki University School of Medicine in Japan. It described one 56-year-old woman who had been treated for malignant peritoneal mesothelioma for 4 years with intravenous vinorelbine followed by cisplatin given into the abdomen. She came in with several weeks of low-grade fever and diarrhea. A barium enema showed a large mass in the middle of the transverse colon, and colonoscopy confirmed it. Biopsy samples from the mass showed sarcomatous tissue with spindle cells. Staining was negative for carcinoembryonic antigen and positive for calretinin. The authors said this supported a diagnosis of malignant peritoneal mesothelioma. The authors reported that the patient had no evidence of asbestos exposure and that the cause of her mesothelioma was unknown. A separate commentary by the journal's associate editor noted that when mesothelioma blocks the bowel, it usually does so by pressing from outside rather than from disease inside the bowel as in this case. The editor advised taking many biopsies. A single case shows what happened to one person, not how often it happens.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (single patient, image-based Focal Point), followed by an editor's commentary
• Who was studied: one 56-year-old woman with malignant peritoneal mesothelioma treated for 4 years; authors at Nagasaki University School of Medicine, Japan
• Exposure: No evidence of asbestos exposure was found; the cause of the mesothelioma was unknown. She had been treated with intravenous vinorelbine and intraperitoneal cisplatin.
• Main results:
  • In this patient, a barium contrast enema showed a large mass in the mid-transverse colon, which was confirmed at colonoscopy
  • Biopsy specimens from the colon lesion showed sarcomatous tissue with spindle cells
  • Immunostaining was carcinoembryonic antigen negative and calretinin positive, which the authors said supported the diagnosis
• The authors' conclusion: The authors stated that the findings supported a diagnosis of malignant peritoneal mesothelioma, and that the cause of this patient's mesothelioma was unknown.

Topics

The National Library of Medicine indexes this study under subjects our site covers: Colon cancer, Mesothelioma, Peritoneal mesothelioma.

Medical terms in this study, explained in our Lexicon: Peritoneal Mesothelioma.

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