Filtration of citrated plasma

Our plain-English summary of Filtration of citrated plasma, by L. Rane, D.M. Baldwin (Science, 1945).

The study

• Authors: L. Rane, D.M. Baldwin
• Journal: Science
• Published: 1945;101(2628):494-6
• Cited by: 3 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

Abstract

Large amounts of fresh citrated plasma can be filtered easily through specially prepared asbestos-composition pads without clotting. A description of the technique is given.

In plain English

This 1945 note in Science described a laboratory method for filtering fresh citrated human plasma through specially prepared asbestos-composition pads. It did not study the health effects of asbestos. The setup placed a clarifying pad (K6) on top of a sterilizing pad (S6) in a stainless steel filter, with a steel screen over the top pad to keep the asbestos from flaking. The pads were treated so that their calcium content was less than 0.01 per cent. Using a single 14 cm pad and a pressure of 15-20 pounds, the authors reported filtering as much as 15-18 liters of plasma without any evidence of clotting, usually at 5-7 liters per hour. They reported that over 200 lots had been filtered this way without a single contamination of the final bulk material. Chemical studies showed no apparent difference between filtered and unfiltered plasma, with details to be reported later. The authors concluded that large amounts of fresh citrated plasma can be filtered easily through these pads without clotting.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: laboratory methods note describing a filtration technique (not a health study)
• Who was studied: Fresh citrated human plasma from Red Cross donor bottles, processed at Lederle Laboratories, Pearl River, N.Y.; over 200 lots filtered (lot size printed as 15-78 liters)
• Exposure: Specially prepared asbestos-composition filter pads (K6 clarifying pad and S6 sterilizing pad) used to filter plasma. A stainless steel screen was placed over the top pad to prevent the asbestos from flaking. No fiber type is named.
• Main results:
  • With a single 14 cm pad at 15-20 pounds pressure, as much as 15-18 liters of plasma were filtered without evidence of clotting
  • Warmed plasma filtered under pressure usually at 5-7 liters per hour
  • Over 200 lots were filtered without a single contamination of the final bulk material
  • Chemical studies indicated no apparent difference between filtered and unfiltered plasma; details were to be reported later
  • The pads were treated to have a calcium content of less than 0.01 per cent
• The authors' conclusion: The authors concluded that large amounts of fresh citrated plasma can be filtered easily through specially prepared asbestos-composition pads without clotting

Related studies

• Toxicity of cell culture medium due to filtration through asbestos pads — W. House (1964)
• Asbestos fibers in wines: relation to filtration process — A. Gaudichet, M. Bientz, et al. (1978)
• Capture efficiency of portable high-efficiency air filtration devices used during building construction activities — D.A. Newcomer, P. LaPuma, et al. (2018)
• A method of treating asbestos filter pads for virus filtration — N.S. Hyslop (1961)
• Certification of probability of sterilization of liquid by filtration — D.M. Portner, C.R. Phillips, et al. (1967)
• Size Separation of Amosite by Filtration and Shaking Methods — T. Lee, R. Walker, et al. (2021)

Browse more research in Science, or return to medical research.