Malignant Mesothelioma

Our plain-English summary of Malignant Mesothelioma, by D.L. Pouliquen, J. Kopecka (Cancers, 2021).

The study

• Authors: D.L. Pouliquen, J. Kopecka
• Journal: Cancers
• Published: 2021;13(14)
• Type of article: Editorial
• Cited by: 4 articles, as counted by NIH iCite
• Read it: PubMed · Publisher · Free full text

Abstract

Malignant mesothelioma (MM) is a rare and aggressive cancer, related to chronic inflammation and oxidative stress caused mainly by exposure to asbestos [...].

In plain English

This was an editorial, not a research study. The two authors, editors of a Special Issue of the journal Cancers on malignant mesothelioma, introduced its 19 contributions, written by 168 authors from 71 affiliations in 13 countries. As background, they described malignant mesothelioma as a rare and aggressive cancer related to chronic inflammation and oxidative stress caused mainly by exposure to asbestos. They noted that although asbestos has been banned for decades in many countries, epidemiologists predict the epidemic will last past 2040. They then described each article in the issue in a sentence or two. Topics included biomarkers, diagnosis, the immune system, imaging, surgery, radiotherapy, an experimental drug and drug therapies. The editorial reported no data of its own. The findings it credits to named authors come from those separate articles, while its opening paragraph gave the editors' general overview of recent research. The authors concluded that the 19 articles might help reach the goal of prolonged survival with maintained quality of life for patients. They added that the articles open prospects for improving early diagnosis and treatment.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: Editorial introducing a journal Special Issue; it briefly describes each contributed article (on biomarkers, diagnosis, immune system, imaging, surgery, radiotherapy and drug treatments) and contains no original research of its own
• Who was studied: No study population; the editorial introduces 19 articles by 168 authors from 71 affiliations in 13 countries on three continents
• Exposure: No exposure was studied. As background, the editorial states malignant mesothelioma is caused mainly by asbestos exposure and that, despite bans, epidemiologists predict the epidemic will last past 2040
• The authors' conclusion: The authors concluded that the 19 articles might contribute to the goal of prolonged survival with maintained quality of life for patients, and open prospects for improving early diagnosis and treatment

Topics

Medical terms in this study, explained in our Lexicon: Malignant Mesothelioma, Chronic Inflammation, Oxidative Stress.

Related studies

• Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway — M. Polimeni, G.R. Gulino, et al. (2016)
• Potential Diagnostic and Prognostic Role of Microenvironment in Malignant Pleural Mesothelioma — I.C. Salaroglio, J. Kopecka, et al. (2019)
• Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma — J. Kopecka, I.C. Salaroglio, et al. (2018)
• Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases — G.R. Gulino, M. Polimeni, et al. (2016)
• Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma — D.L. Pouliquen, B. Nawrocki-Raby, et al. (2017)
• Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine — D. Roulois, S. Deshayes, et al. (2016)

Browse more research in Cancers, or return to medical research.