Prominent in situ component in a pleural malignant mesothelioma

Our plain-English summary of Prominent in situ component in a pleural malignant mesothelioma, by F. Bono, M. Lombardi (International Journal of Surgical Pathology, 2015).

The study

• Authors: F. Bono, M. Lombardi
• Journal: International Journal of Surgical Pathology
• Published: 2015;23(2):127-9
• Type of article: Case report
• Cited by: 2 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

In plain English

This article is a short "Images in Pathology" case report describing one patient. The authors noted that the term mesothelioma in situ is rarely used without accompanying invasive tumor, largely because of the risk of overdiagnosis. The patient was a 71-year-old man with a past history of asbestos exposure; the article gives no further exposure details. He presented with fluid around the lung (pleural effusion), and a CT scan was suspicious for malignant mesothelioma. A pleural biopsy showed mesothelial-type tumor cells growing into the underlying tissue. In one well-oriented part of the sample, the authors saw an obvious focus of in situ mesothelioma lying over an area of clear invasion by the tumor. The in situ part was partly flat and single-layered and partly raised and polyp-like. On special staining, both the invasive and in situ parts were positive for calretinin, CK5/6 and CK7 and negative for CEA, WT1 and TTF-1. As a single case report, it describes one patient, not a rate.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (Images in Pathology)
• Who was studied: one 71-year-old man with pleural effusion and a CT scan suspicious for malignant mesothelioma; the work was done at a pathology consultation centre in Milan, Italy
• Exposure: past history of asbestos exposure; fiber type, job and dose not stated
• Main results:
  • The pleural biopsy showed cuboidal medium-sized cells with mesothelial features infiltrating a fibromyxoid stroma
  • In one well-oriented part of the specimen there was an obvious focus of in situ mesothelioma overlying an area of clear stromal invasion by the tumor
  • The in situ component was partly flat and monolayered and partly elevated and polypoid
  • Both the invasive and in situ components were positive for calretinin, CK5/6 and CK7 and negative for CEA, WT1 and TTF-1

Topics

The National Library of Medicine indexes this study under subjects our site covers: Lung cancer, Mesothelioma.

Medical terms in this study, explained in our Lexicon: Malignant Mesothelioma.

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