Resveratrol and cisplatin in a malignant mesothelioma cell model

Our plain-English summary of Resveratrol and cisplatin in a malignant mesothelioma cell model, by S. Chirumbolo, G. Bjørklund (Food and Chemical Toxicology, 2016).

The study

• Authors: S. Chirumbolo, G. Bjørklund
• Journal: Food and Chemical Toxicology
• Published: 2016;98(Pt B):308-309
• Type of article: Letter
• Read it: PubMed · Publisher

In plain English

This is a letter to the editor, not a study. The two authors commented on an earlier laboratory paper by Lee and colleagues (2016), in the same journal, which tested the cancer drug cisplatin together with resveratrol, a plant compound, on malignant mesothelioma cells grown in the laboratory. As the letter describes it, Lee and colleagues reported that the combination drove MSTO-211H cells into apoptosis (programmed cell death), while H-2452 cells resisted it and showed more autophagy, a process in which cells break down and recycle their own parts. The letter reported no experiments or data of its own and did not address asbestos exposure. Citing other published work, the authors argued that cisplatin and resveratrol can each promote autophagy, and said they doubted that the two acted together to dampen it. They also wrote that calcium was missing from Lee and colleagues' discussion. In their opinion, cisplatin added to resveratrol's cell-killing effect where oxidative stress overwhelmed the cells' ability to mount a survival response.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: Letter to the editor commenting on another group's published laboratory study (Lee et al., 2016); no original research
• Who was studied: No population of its own. The letter discusses Lee et al.'s work on two malignant mesothelioma cell lines, MSTO-211H and H-2452
• Exposure: Cisplatin and resveratrol, alone and combined, in mesothelioma cells in the laboratory. No asbestos exposure is discussed
• Main results:
  • As described in the letter, Lee et al. (2016), not the letter's authors, reported that the cisplatin and resveratrol combination failed to kill H-2452 cells, which showed an increased autophagic response
  • The letter's authors argued, citing other studies, that both cisplatin and resveratrol can induce autophagy
  • The letter's authors said they doubted that cisplatin and resveratrol acted together to dampen the autophagy triggered by resveratrol
  • The letter's authors wrote that calcium was missing from Lee et al.'s discussion
• The authors' conclusion: The authors gave their opinion that cisplatin added to the cell-killing (pro-apoptotic) effect of resveratrol in conditions where oxidative stress (ROS production) overwhelmed the cells' ability to activate a survival response

Topics

The National Library of Medicine indexes this study under subjects our site covers: Lung cancer, Mesothelioma.

Medical terms in this study, explained in our Lexicon: Cisplatin, Malignant Mesothelioma.

Related studies

• Cisplatin and resveratrol induce apoptosis and autophagy following oxidative stress in malignant mesothelioma cells — Y.J. Lee, G.J. Lee, et al. (2016)
• Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation — Y.J. Lee, J.H. Im, et al. (2012)
• Resveratrol and clofarabine induces a preferential apoptosis-activating effect on malignant mesothelioma cells by Mcl-1 down-regulation and caspase-3 activation — Y.J. Lee, Y.J. Lee, et al. (2015)
• Knockdown of Bcl-xL enhances growth-inhibiting and apoptosis-inducing effects of resveratrol and clofarabine in malignant mesothelioma H-2452 cells — Y.J. Lee, I.S. Hwang, et al. (2014)
• Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells — Y.J. Lee, Y.J. Lee, et al. (2013)
• The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1 — K.A. Lee, Y.J. Lee, et al. (2012)

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