Translocation X;12 in mesothelioma

Our plain-English summary of Translocation X;12 in mesothelioma, by P. Dal Cin, I. De Wever, P. Moerman, et al (Cancer Genetics and Cytogenetics, 1991).

The study

• Authors: P. Dal Cin, I. De Wever, P. Moerman, H. Van den Berghe
• Journal: Cancer Genetics and Cytogenetics
• Published: 1991;55(1):115-8
• Type of article: Case report
• Cited by: 8 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

Abstract

Cytogenetic analysis of a non-asbestos-related mesothelioma showed a translocation between chromosomes X and 12 as the only chromosome abnormality, with breakpoints at bands q22 and p13, respectively.

PubMed has no abstract for this study. This is the authors' abstract, copied from the article.

In plain English

This short communication was a case report from the University of Leuven, Belgium, about one patient: a 63-year-old man, a retired bank administrator, with no known asbestos exposure. Over 5 months the patient had episodes of disorientation and loss of consciousness. Severe low blood sugar (hypoglycemia) was found, along with a dense mass filling the lower half of the right chest. The tumor weighed 2,500 g and was attached to the lining (visceral pleura) of the right lower lung. Surgeons removed it completely together with the lower lobe of the right lung, and afterwards the patient's blood sugar was normal. It was diagnosed as a potentially malignant localized fibrous mesothelioma. Chromosome analysis of 25 dividing tumor cells (metaphases) grown in culture found that all of them carried an exchange of material between chromosomes X and 12, written t(X;12)(q22;p13), as the only chromosome change. The patient's constitutional chromosome pattern was normal. The authors concluded that the relevance of the 12p13 breakpoint in mesothelioma not related to asbestos should be studied.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (single patient) with cytogenetic (chromosome) analysis of the tumor
• Who was studied: One 63-year-old man, a bank administrator who had retired 3 years earlier, treated at the University of Leuven, Belgium; the dates of treatment are not given (the article was received in October 1990)
• Exposure: No documented or known asbestos exposure; the article does not describe how the exposure history was assessed
• Main results:
  • The patient had 5 months of episodes of disorientation and loss of consciousness; the mass was tentatively diagnosed as a soft tissue tumor or mesothelioma causing hypoglycemia
  • The tumor was removed completely en bloc with the lower lobe of the right lung
  • After surgery the patient's course was uneventful and blood sugar was normal
  • The removed tumor weighed 2,500 g and was attached to the visceral pleura of the right lower lung
  • The tumor was diagnosed as a potentially malignant localized fibrous mesothelioma
  • Chromosome analysis was done on 25 G-banded metaphases from the tumor cells
  • All analyzed tumor cells showed a translocation between chromosomes X and 12 (bands q22 and p13) as the only chromosome change
  • The patient's constitutional karyotype was normal (46,XY)
• The authors' conclusion: The authors concluded that the relevance of the 12p13 breakpoint in non-asbestos-related mesothelioma should be studied

Topics

The National Library of Medicine indexes this study under subjects our site covers: Mesothelioma.

Medical terms in this study, explained in our Lexicon: Translocation, Mesothelioma.

Related studies

• Translocation (3;3)(p14;q29) as the primary chromosome abnormality in a peritoneal mesothelioma — M.R. Teixeira, K.E. Giercksky, et al. (1998)
• Translocation (2;3)(p21;p26) as the sole anomaly in a benign localized fibrous mesothelioma — F. Mertens, R. Willén, et al. (1996)
• Chromosome 3 and 12p rearranged in a well-differentiated peritoneal mesothelioma — H.J. Decker, F.P. Li, et al. (1990)
• Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma — Y.P. Hung, F. Dong, et al. (2018)
• Anaplastic lymphoma kinase (ALK) translocation in paediatric malignant peritoneal mesothelioma: a case report of novel ALK-related tumour spectrum — K. Loharamtaweethong, N. Puripat, et al. (2016)
• Hibernoma-like Changes and TFE3 Expression in Mesothelioma Mimicking TFE3-Translocation Renal Cell Carcinoma: A Diagnostic Pitfall — D. Hoton, M. Luyckx, et al. (2021)

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