14 results for “Reaction Department”
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Medical study · Medical research · 2016
BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas
…help diagnose sarcomatous and desmoplastic mesotheliomas. These tumors can be hard to distinguish from organizing pleuritis, a benign reaction of the pleura. The authors tested tissue from 20 such pleural mesotheliomas, from 18 men and 2…
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Medical study · Medical research · 1985
Pathologic changes in the small airways of the guinea pig after amosite asbestos exposure
… where these fibers penetrated the airway walls, an interstitial inflammatory and fibrotic reaction (asbestosis) occurred. It is concluded that 1) amosite asbestos produces diffuse abnormalities throughout the noncartilagenous airways and possibly the cartilagenous airways as well…
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Medical study · Medical research · 1983
Small-airway lesions in patients exposed to nonasbestos mineral dusts
…which they call mineral dust airways disease, is a nonspecific reaction of the small airways to inorganic particulates. The presence of such changes casts considerable doubt on the theory that small-airway abnormalities in asbestos workers…
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Medical study · Medical research · 2018
Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma
…methylation, and copy number status of miR-137 and its host gene MIR137HG were assessed by polymerase chain reaction. Luciferase reporter assays confirmed a direct interaction between miR-137 and Y-box binding protein 1 gene…
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Medical study · Medical research · 2017
Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural Mesothelioma
…from samples from patients undergoing an operation (pleurectomy with or without decortication). MicroRNA expression was analyzed by reverse-transcriptase quantitative polymerase chain reaction. Regulation of PD-L1 expression in cell lines was assessed after transfection with…
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Medical study · Medical research · 1985
Immunohistochemical staining for vimentin and keratin in malignant mesothelioma
…were negative. In the mesotheliomas that did stain, both epithelial and spindled elements gave a positive reaction. Three alcohol-fixed lung cancers and two blocks of alcohol-fixed pleura failed to stain for vimentin. By contrast…
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Medical study · Medical research · 2013
ZIC1 is silenced and has tumor suppressor function in malignant pleural mesothelioma
…cell growth and apoptosis, was investigated in MPM cell lines and tumors. ZIC1 expression and promoter methylation were evaluated in MPM cell lines and tumor samples by quantitative polymerase chain reaction (PCR), Combined Bisulfite Restriction Analysis…
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Medical study · Medical research · 1998
Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall
…titanium dioxide. Explants were then maintained in air organ culture, and the expression of genes encoding for various mediators and matrix components assessed by reverse transcriptase-polymerase chain reaction (RT-PCR). At 7 d, all dusts…
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Medical study · Medical research · 2012
Increased circulating miR-625-3p: a potential biomarker for patients with malignant pleural mesothelioma
…healthy controls. miRNAs with significantly different abundance between cases and controls were validated in a larger series of MM patients and in an independent series of MM patients using quantitative real-time polymerase chain reaction. Levels…
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Medical study · Medical research · 2018
New Insights on Diagnostic Reproducibility of Biphasic Mesotheliomas: A Multi-Institutional Evaluation by the International Mesothelioma Panel From the MESOPATH Reference Center
…the usefulness of FISH detection of CDKN2A(p16) HD compared to BAP1 loss on the spindle cell component for the separation in ambiguous cases between benign florid stromal reaction from true sarcomatoid component of biphasic mesothelioma…
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Medical study · Medical research · 2016
New Markers for Separating Benign From Malignant Mesothelial Proliferations: Are We There Yet?
This was a literature review of laboratory tests for telling malignant mesothelioma from benign mesothelial reactions. The authors wrote that five older stains (GLUT-1, p53, IMP-3, epithelial membrane antigen and desmin) worked only in…
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Medical study · Medical research · 2016
Utility of BAP1 Immunohistochemistry and p16 (CDKN2A) FISH in the Diagnosis of Malignant Mesothelioma in Effusion Cytology Specimens
…might also be useful in effusion cytology specimens, we examined 15 biopsies of epithelial mesotheliomas and 3 benign mesothelial reactions and corresponding effusion cytology paraffin-embedded cell blocks. Four cytology specimens were too scanty for p16…
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Medical study · Medical research · 2016
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification
…Citing other studies, the authors described tests that showed promise but needed further confirmation. These included p16 FISH and BAP1 staining for separating mesothelioma from benign reactions, though neither finds every mesothelioma. They included a preliminary…
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Medical study · Medical research · 2003
Bronchiolitis caused by occupational and ambient atmospheric particles
…hyperplasia, probably through oxidant mechanisms. These reactions are intrinsic properties of the particles and do not require exogenous inflammatory cells. There is considerable evidence that individuals with occupational exposure to a wide variety of mineral dusts…