5 results for “General Electric”
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Medical study · Medical research · 2003
Asbestos-induced apoptosis is protein kinase C delta-dependent
…dnPKC alpha. Activities of PKC alpha and PKC zeta increased after exposure to asbestos, but neither isoform migrated to mitochondria. A general inhibitor of PKCs, bisindolylmaleimide I, had no effect on asbestos-induced apoptosis. Hydrogen peroxide…
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Medical study · Medical research · 1996
Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers
…In this article, the general properties of asbestos fibers will be discussed with an emphasis on chemical and physical features implicated in tumorigenesis. We will then provide a brief overview of the clinical features and treatment…
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Medical study · Medical research · 1994
Carcinogenesis and related cell and tissue responses to asbestos: a review
…of lung cancer. Several caveats important in the interpretation of these data include the general lack of dose-response protocols both for in vivo and for in vitro studies as well as the absence, in many…
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Medical study · Medical research · 2004
Asbestos and the pleura: a review
…the evidence indicated plaques do not increase cancer risk, though this was far from a universal view. They reported general agreement that diffuse pleural thickening can cause significant restrictive ventilatory impairment. For mesothelioma, they reviewed incidence…
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Medical study · Medical research · 2011
Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis
…and cell cycle regulation. Although it is unclear whether the present findings are specific to chrysotile asbestos or would be observed after inhalation of other fibers in general, these results highlight new potential mechanisms and therapeutic…