8 results for “Reaction Department”
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Medical study · Medical research · 2011
Auto-antibodies to β-F1-ATPase and vimentin in malignant mesothelioma
…against proteins from mesothelioma cell lines. They found no antibody reaction common to the patients. Serum from one patient strongly recognised proteins later identified as vimentin and the beta chain of ATP synthase (beta-F1-ATPase…
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Medical study · Medical research · 2000
Simian virus (SV) 40 like sequences in cell lines and tumour biopsies from Australian malignant mesotheliomas
…its gene products in tissue derived from mesotheliomas would detract from this possibility. We used polymerase chain reaction from three pairs of primers to amplify different regions of the large T antigen from DNA from cell…
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Medical study · Medical research · 2017
Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural Mesothelioma
…from samples from patients undergoing an operation (pleurectomy with or without decortication). MicroRNA expression was analyzed by reverse-transcriptase quantitative polymerase chain reaction. Regulation of PD-L1 expression in cell lines was assessed after transfection with…
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Medical study · Medical research · 2001
Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma
…Coupled with this, we have previously noted a common serological reaction to the beta isoform of topoisomerase II, suggesting that it may be aberrantly expressed in patients with mesothelioma. We assessed the expression of topoisomerase II…
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Medical study · Medical research · 1998
Cytokine gene therapy or infusion as treatment for solid human cancer
…excretion was detectable. At each cycle vaccinia-IL-2 mRNA (SQ [semi-quantitative] reverse transcription polymerase chain reaction) was maximal 24-72 h following injection reduced at 8 days and faded by 21 days. No tumor…
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Medical study · Medical research · 2012
Increased circulating miR-625-3p: a potential biomarker for patients with malignant pleural mesothelioma
…healthy controls. miRNAs with significantly different abundance between cases and controls were validated in a larger series of MM patients and in an independent series of MM patients using quantitative real-time polymerase chain reaction. Levels…
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Medical study · Medical research · 2000
Serologic responses in patients with malignant mesothelioma: evidence for both public and private specificities
…protein. Antibodies to topoisomerase II beta were found in 13 of 14 patients and in 6 of 16 volunteers, though the volunteers' reactions were generally weak. Antibodies to U2AF(65) were found in two patients. Each…
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Medical study · Medical research · 2001
Localised spontaneous regression in mesothelioma -- possible immunological mechanism
…lobe. Blood samples from her last 11 months showed antibodies against mesothelioma. Two of these reactions faded and one stayed stable. The authors judged this strong circumstantial evidence linking the immune cells to the regression. They…