5 results for “Reaction Department”
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Medical study · Medical research · 2016
Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma
…protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3). Real time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to assess the steady-state levels of AM…
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Medical study · Medical research · 2018
Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service
…hypersensitivity reactions are commonly encountered. The allergic clinical symptoms are variable and unpredictable. The aim of this study was to identify the characteristics of hypersensitivity reactions and to assess the value of skin tests for platinum…
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Medical study · Medical research · 2021
Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors
…kg was selected as the recommended phase II dose. Seven patients (12%) reported infusion-related reactions. Treatment-related grade ≥3 treatment-emergent adverse events were pericardial effusion, colitis, infusion-related reaction, and pleural effusion (n=1 each…
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Medical study · Medical research · 2014
Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma
…in the two arms, aside from infusion reactions which occurred in 70% of patients treated with CBP501. While this randomized phase II trial met its primary endpoint of PFS at 4 months, other parameters such as…
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Medical study · Medical research · 2020
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma
…mg/kg and used for cohort expansion. The most common treatment-related adverse events (AEs) were nausea (56%), decreased appetite (36%), infusion reactions (36%), decreased neutrophil counts (36%), and fatigue (33%). The confirmed ORR was 39%…