3 results for “Reaction Department”
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Medical study · Medical research · 2005
The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer
…genes that are regulated by mineral dusts. Using a differential display reverse transcription polymerase chain reaction technique and mRNAs of alveolar macrophages from both normal individuals and coal miners, we identified a novel mineral dust-induced…
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Medical study · Medical research · 1998
Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis
…caused lung immune cells to release an inflammatory signaling protein (TNF-alpha), which the authors linked to metal-driven free radical reactions. The authors concluded that their studies support the hypothesis that ROS are involved in…
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Medical study · Medical research · 1999
Role of transcription factor NF-kappaB in asbestos-induced TNFalpha response from macrophages
…were inhibited by oxygen radical scavengers and were enhanced by antioxidant enzyme inhibitors. These results indicate that asbestos-induced TNFalpha gene expression is mediated through a process that involves NF-kappaB activation and free radical reactions.