12 results for “General Electric”
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Medical study · Medical research · 2016
Impact of induction therapy on postoperative outcome after extrapleural pneumonectomy for malignant pleural mesothelioma: does induction-accelerated hemithoracic radiation increase the surgical risk?
This retrospective study from Toronto General Hospital, Canada, reviewed patients who had extrapleural pneumonectomy for malignant pleural mesothelioma between January 2001 and December 2014. In this operation the lung, outer chest lining, diaphragm and heart sac…
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Medical study · Medical research · 2014
A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: the "SMART" approach for resectable malignant pleural mesothelioma
This phase I/II feasibility study came from Princess Margaret Cancer Centre and Toronto General Hospital, Canada. It tested a treatment, SMART, for surgically removable malignant pleural mesothelioma. It did not study asbestos exposure. From November…
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Medical study · Medical research · 2016
SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma
…It did not study asbestos exposure. The authors measured gene activity in nine tumor samples from Toronto General Hospital and in four mesothelioma cell lines. They reported that both genes were overexpressed in a majority of…
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Medical study · Medical research · 2013
Use of the posterior pericardium to cover the bronchial stump after right extrapleural pneumonectomy
…a study of asbestos exposure. The author, a thoracic surgeon at Toronto General Hospital, described a way to cover the stapled end (stump) of the right main bronchus after right extrapleural pneumonectomy. This is an operation…
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Medical study · Medical research · 2008
Malignant mesothelioma 2008
…been studied in recent trials for its effects on disease free and overall survival This review provides a general overview of malignant mesothelioma with a summary of the most significant articles from within the past year…
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Medical study · Medical research · 2015
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma
This laboratory study read the protein-coding DNA (the 'exome') of tumors from 22 people diagnosed with malignant pleural mesothelioma at the New York University General Thoracic Surgery Service. Each tumor was compared with the same…
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Medical study · Medical research · 2020
Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma
…Therefore, 7 of 155 apparently unrelated mesothelioma patients carried BLM+/- mutations, significantly higher (P = 6.7E-10) than the expected frequency in a general, unrelated population from the gnomAD database, and 2 of 7 carried…
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Medical study · Medical research · 2016
Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma
…measurements are reported in this article. Gene-activity testing showed both genes highly active in most of 13 tumor samples from Toronto General Hospital and in four mesothelioma cell lines, but low in a normal mesothelial…
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Medical study · Medical research · 1999
New molecular and epidemiological issues in mesothelioma: role of SV40
…was difficult to draw conclusions. They suggested that SV40 and asbestos might act together. The authors concluded that it would be premature to reach definitive conclusions about SV40's role in mesothelioma in the general population.
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Medical study · Medical research · 2004
Translation research: from accurate diagnosis to appropriate treatment
…relating to the asbestos related cancer mesothelioma, it should be stressed that the general approach outlined throughout this review is readily applicable to other diseases with an underlying molecular basis. Through the integration of molecular-based…
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Medical study · Medical research · 2020
A liquid biopsy for detecting circulating mesothelial precursor cells: A new biomarker for diagnosis and prognosis in mesothelioma
…mesothelioma. The presence of different subtypes of MPC have a prognostic value that could be of assistance with clinical decisions in patients with MPM. Princess Margaret Hospital Foundation Mesothelioma Research Fund, Toronto General & Western Hospital Foundation.
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Medical study · Medical research · 2016
Consensus Report of the 2015 Weinman International Conference on Mesothelioma
…as high mobility group box 1 and fibulin-3, are promising. There was general agreement that current treatment for MM, which is based on surgery and standard chemotherapy, has a modest effect on the overall survival…