4 results for “Reaction Department”
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Medical study · Medical research · 2021
Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors
…kg was selected as the recommended phase II dose. Seven patients (12%) reported infusion-related reactions. Treatment-related grade ≥3 treatment-emergent adverse events were pericardial effusion, colitis, infusion-related reaction, and pleural effusion (n=1 each…
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Medical study · Medical research · 2014
Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma
…in the two arms, aside from infusion reactions which occurred in 70% of patients treated with CBP501. While this randomized phase II trial met its primary endpoint of PFS at 4 months, other parameters such as…
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Medical study · Medical research · 2010
WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
…lung cancer were vaccinated, and 10 could be evaluated for immune response. Seven of the 12 had mild (grade 1) injection-site reactions; no other side effects attributable to the vaccine were noted. Six of nine…
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Medical study · Medical research · 2020
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma
…mg/kg and used for cohort expansion. The most common treatment-related adverse events (AEs) were nausea (56%), decreased appetite (36%), infusion reactions (36%), decreased neutrophil counts (36%), and fatigue (33%). The confirmed ORR was 39%…