13 results for “Reaction Department”
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Medical study · Medical research · 1996
Distinctive profile of alveolar macrophage-derived cytokine release induced by fibrogenic and nonfibrogenic mineral dusts
…BAL) for BAL cell populations and cytokine production in conjunction with histopathological assessment of lung tissue. Chrysotile B and short 4T30 chrysotile fibers induced chronic inflammatory reactions characterized by alveolar macrophage (AM) accumulation that resulted, respectively…
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Medical study · Medical research · 1993
Bidirectional modulation of TNF-alpha production by alveolar macrophages in asbestos-induced pulmonary fibrosis
…alpha mRNA in AMs. These data indicate that lower levels of TNF-alpha resulted from inhibition at the gene expression level and provide evidence for bidirectional modulation of TNF-alpha production by AMs during inflammatory reactions.
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Medical study · Medical research · 1986
Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis
…proliferation, and collagen deposition. To evaluate the potential involvement of alveolar macrophages in the subsequent fibrogenic reaction, the authors studied the effects of macrophages from normal and asbestos-treated rats upon lung fibroblast proliferation in vitro…
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Medical study · Medical research · 1985
An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats
…structure, and surface charge, the lung tissue reaction differed considerably. Lungs of animals exposed to UICC chrysotile B showed significant pathological alterations as early as 7 days following treatment. The lesions were localized in and around…
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Medical study · Medical research · 1983
Effect of asbestos on the metabolism of vasoactive substances in isolated perfused guinea pig lungs
…The tissue response consisted of both inflammatory reaction of terminal and respiratory bronchioles and diffuse alveolar septal infiltration with interstitial fibrosis. The reaction was characterized at six months by a progressive bronchiolitis obliterans with fibroblastic proliferation…
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Medical study · Medical research · 1989
Rat lung reactivity to natural and man-made fibrous silicates following short-term exposure
…more significantly to attapulgite and Fiberfrax although the tissue reaction differed considerably for these two materials. While attapulgite, at doses up to 10 mg caused minimal reactions characterized by mononuclear cell infiltration mainly in the alveolar…
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Medical study · Medical research · 1987
The lung biological activity of American attapulgite
…not an inert material for lung tissue; it does produce a macrophagic and neutrophilic alveolitis in the early inflammatory phase of lung reaction with peribronchiolar involvement in some sheep. Whether or not this initial attapulgite induced…
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Medical study · Medical research · 1991
Contributions of experimental asbestosis in sheep to the understanding of asbestosis
…to 5 years. The authors described four tissue reactions to asbestos: no-retention, low-retention, high-retention and intermediate. They suggested that the intermediate reaction might explain non-progressive cases of minimal asbestosis. Exposure dose and…
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Medical study · Medical research · 1985
Selective exposure and analysis of the sheep tracheal lobe as a model for toxicological studies of respirable particles
…at Day 1) and only macrophages after; lung histology documented an early macrophagic alveolitis which decreased to less than 10% of the initial inflammatory reaction at Day 60, without other distortion of the lung and airway…
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Medical study · Medical research · 1985
Characterization of the bronchoalveolar cellular response in experimental asbestosis. Different reactions depending on the fibrogenic potential
This was an animal experiment in male Wistar rats. Each rat received a single injection into the windpipe of saline (control), 5 mg of UICC chrysotile B asbestos, or 5 mg of very short 4T30 chrysotile fibers. Lung washings (bronchoalveolar lavage)…
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Medical study · Medical research · 1986
Cytokine regulation of lung fibroblast proliferation. Pulmonary and systemic changes in asbestos-induced pulmonary fibrosis
…later loss of the blood-cell inhibitor may be a consequence or amplifier of fibrosis. They noted that, given the injection method, their data do not relate to very early reactions to low-level inhaled asbestos.
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Medical study · Medical research · 1991
Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis
Alveolar macrophages (AM) and their production of interleukin-1-like activity (IL-1) and macrophage-derived growth factor for fibroblasts (MDGF) were examined during chronic inflammatory reactions leading to either granuloma formation or fibrosis. Groups of…
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Medical study · Medical research · 1983
Asbestos-related increase in pulmonary levels of vasoactive intestinal peptide (VIP)
…the pathogenesis of asbestos-related diseases. Exposure to asbestos causes chronic inflammatory reactions in the lung which may lead to fibrosis (1) and increase the incidence of pleuropulmonary cancers (2). Little is known concerning the biochemical…