7 results for “Reaction Department”
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Medical study · Medical research · 2012
Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer
…carcinogenesis in humans. Intraperitoneal administration of ferric nitrilotriacetate initiates a Fenton reaction in renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatments. We performed high…
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Medical study · Medical research · 2017
In response to Sharing different perspectives to understand asbestos-induced carcinogenesis: A comment to Jiang et al. (2016) by Alessandro Francesco Gualtieri (2017)
…hemoglobin. They stated that catalytic Fe(II) is more important than Fe(III) because it initiates a Fenton reaction. They described two roles of macrophages: scavenging fibers and promoting inflammation. They stated that chrysotile is carcinogenic…
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Medical study · Medical research · 2016
Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis
…its effects on asbestos-induced peritoneal inflammation and iron deposition, as well as oxidative stress. Nitrilotriacetate was used to promote an iron-catalyzed Fenton reaction as a positive control. Desferal significantly decreased peritoneal fibrosis, iron deposition…
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Medical study · Medical research · 2012
Iron overload signature in chrysotile-induced malignant mesothelioma
…closely associated with iron overload: repeated administration of an iron chelator, nitrilotriacetic acid, which promotes the Fenton reaction, significantly reduced the period required for carcinogenesis; massive iron deposition was found in the peritoneal organs with high…
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Medical study · Medical research · 2008
Characteristics and modifying factors of asbestos-induced oxidative DNA damage
…Natural iron chelators, such as citrate, adenosine 5'-triphosphate and guanosine 5'-triphosphate, did not inhibit this reaction. Second, we used time-lapse video microscopy to evaluate how cells cope with asbestos fibers. RAW264.7 cells…
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Medical study · Medical research · 2014
ERC/mesothelin is expressed in human gastric cancer tissues and cell lines
…MKN-7, MKN-74, NUGC-3, NUGC-4 and TMK-1) using reverse transcription-polymerase chain reaction, flow cytometry, immunohistochemistry and immunoblotting. We also examined the N-ERC/mesothelin concentrations in the supernatants of cultured cells…
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Medical study · Medical research · 2019
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia
…and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO2, bicarbonate and H+. CA9…