4 results for “Reaction Department”
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Medical study · Medical research · 2005
The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer
…genes that are regulated by mineral dusts. Using a differential display reverse transcription polymerase chain reaction technique and mRNAs of alveolar macrophages from both normal individuals and coal miners, we identified a novel mineral dust-induced…
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Medical study · Medical research · 1998
Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis
…caused lung immune cells to release an inflammatory signaling protein (TNF-alpha), which the authors linked to metal-driven free radical reactions. The authors concluded that their studies support the hypothesis that ROS are involved in…
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Medical study · Medical research · 1999
Role of transcription factor NF-kappaB in asbestos-induced TNFalpha response from macrophages
…were inhibited by oxygen radical scavengers and were enhanced by antioxidant enzyme inhibitors. These results indicate that asbestos-induced TNFalpha gene expression is mediated through a process that involves NF-kappaB activation and free radical reactions.
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Medical study · Medical research · 1997
The role of oxygen free radicals in occupational and environmental lung diseases
…ROS-induced lung injury at different target levels may contribute to similar patterns of cell injury and alterations at the molecular level by initiation, propagation, and autocatalytic chain reactions. Intracellular signalling, activation and inactivation of enzymes…