1 result for “Reaction Department”
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Medical study · Medical research · 2006
Biocatalytic ammonolysis of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester: preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin
…temperatures, and amounts of enzyme and ammonium carbamate. Adding calcium chloride raised the amide yield to 79%. Placing Ascarite above the reaction mixture, where it was presumed to absorb carbon dioxide, raised the yield to 95%…