558 results for “Reaction Department”, page 11 of 28
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Medical study · Medical research · 2019
Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture
…EGFR expression associating with worse outcomes after Photofrin-mediated PDT for MPM, and the extensive desmoplastic reaction associated with MPM influences tumor phenotype and therapeutic response. Since extracellular matrix (ECM) proteins accrued during stroma development can…
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Medical study · Medical research · 2020
LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma
…that could act as MPM biomarkers. We carried out additional molecular analyses of these potential markers using MPM patient tissue samples via quantitative polymerase chain reaction. We identified Lysyl oxidase (LOX), Lysyl oxidase homologs 1&2…
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Medical study · Medical research · 2024
Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases
…length was also determined in samples from MM patients before and after chemotherapy. Telomere length was determined by monochromatic multiplex quantitative polymerase chain reaction (PCR), while competitive allele-specific PCR was used to genotype hTERT rs10069690…
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Medical study · Medical research · 2018
BAP1 gene mutations in Egyptian patients with advanced sporadic malignant pleural mesothelioma (MPM): relation with clinical outcomes and survival
…and treated as advanced MPM. BAP1 gene mutations were assessed from circulating tumor cells (CTCs) by polymerase chain reaction (PCR) and sequencing and these mutations have been confirmed using the tumor tissue. BAP1 immunohistochemistry was performed…
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Medical study · Medical research · 2017
In response to Sharing different perspectives to understand asbestos-induced carcinogenesis: A comment to Jiang et al. (2016) by Alessandro Francesco Gualtieri (2017)
…hemoglobin. They stated that catalytic Fe(II) is more important than Fe(III) because it initiates a Fenton reaction. They described two roles of macrophages: scavenging fibers and promoting inflammation. They stated that chrysotile is carcinogenic…
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Medical study · Medical research · 2018
In vitro genotoxicity of asbestos substitutes induced by coupled stimulation of dissolved high-valence ions and oxide radicals
…acellular ·OH which formed at the fiber surface at sites with loose/unsaturated bonds, as well as by catalytic reaction through dissolved iron. Accumulated mechanical and radical stimulation induced the intracellular reactive oxygen species (ROS) elevation…
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Medical study · Medical research · 2015
DNA copy number gains in malignant pleural mesothelioma
…The molecular pathogenesis of MPM remains unclear. The present study analyzed the frequency of various genomic copy number gains (CNGs) in MPM using reverse transcription-quantitative polymerase chain reaction. A total of 83 primary MPMs and…
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Medical study · Medical research · 2017
Magnesium oxide production from chrysotile asbestos detoxification with oxalic acid treatment
…treatments destructed the Chr structure while a new biomaterial, Glushinskite (Gls) was formed by the reaction between Oxac with the outer Brucite (Brc) (MgO2) layer surface of Chr. Oxac 0.05M was selected as the optimal…
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Medical study · Medical research · 2021
Re-evaluating the pathogenicity of the c.783+2T>C BAP1 germline variant
…None of the three available tumors showed an allelic loss, there was no discernable effect on alternative splicing based on reverse-transcription polymerase chain reaction, and there was no decrease or loss of somatic protein expression…
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Medical study · Medical research · 2020
Attenuation of oxidative stress and chromosomal aberrations in cultured macrophages and pulmonary cells following self-sustained high temperature synthesis of asbestos
…However, there was an attenuation of redox status imbalance and an absence of chromosomal aberrations, which probably reflects the loss of the asbestos fibrous structure following SHS reaction, as demonstrated by electron microscopy analyses. In conclusions…
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Medical study · Medical research · 2020
Efficient separation of Zn(Ⅱ) from Cd(Ⅱ) in sulfate solution by mechanochemically activated serpentine
…in the presence of SO42-. By adjusting the parameters including grinding intensity, reaction temperature, serpentine dosage and salt species, the optimum conditions were determined and a 92% separation rate of Zn(Ⅱ) and Cd(Ⅱ) ions…
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Medical study · Medical research · 2017
A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair
…BAP1 and investigate the effects of its expression on drug sensitivity in MPM. Expression of BAP1 isoforms was detected by quantitative polymerase chain reaction in MPM and normal mesothelium cell lines and tumor and nontumor samples…
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Medical study · Medical research · 2020
Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes
…naïve CD8+ T cells following antigen stimulation. Exposure to chrysotile B asbestos suppressed the differentiation of CTLs during the mixed lymphocyte reaction (MLR) and was associated with a decrease in proliferation of CD8+ T cells. Additionally…
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Medical study · Medical research · 2020
Evaluation of soluble mesothelin-related peptides and MSLN genetic variability in asbestos-related diseases
…154 had MM. Serum SMRP levels were determined using sandwich enzyme-linked immunosorbent assay. All subjects were genotyped for MSLN rs1057147 polymorphism using competitive allele-specific polymerase chain reaction. Nonparametric tests, logistic and Cox regression were…
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Medical study · Medical research · 2016
Histopathology of removed indwelling pleural catheters from patients with malignant pleural diseases
…the lumen of 11 IPCs (27%). A foreign body giant cell reaction was present at the cuff site in all the 29 IPC in which the subcutaneous cuff was examined. Acute (n = 10) and/or…
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Medical study · Medical research · 2020
Chrysotile asbestos treated with phosphoric acid as an adsorbent for ammonia nitrogen
…its use is banned for many applications. The idea was to obtain a compound that could immobilize phosphate by triggering a reaction between the magnesium oxide and hydroxide contained in the mineral, without causing phosphate leaching…
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Medical study · Medical research · 2016
Population pharmacokinetics and exposure-response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection
…models. Amatuximab PK was best described by a two-compartment model with parallel linear and nonlinear elimination pathways. Body weight and an antidrug antibodies reaction with the titer >64 affected volume of distribution and clearance, respectively…
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Medical study · Medical research · 2021
Herpes Simplex Virus Meningoencephalitis Following Pulse-Dose Methylprednisolone: A Case Report and Literature Review
…days, the patient developed a fever and worsening encephalopathy. A lumbar puncture showed elevated nucleated cells and positive polymerase chain reaction for herpes simplex virus 1 in the cerebrospinal fluid, confirming the diagnosis of HSVE. Acyclovir…
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Medical study · Medical research · 2018
Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma
…methylation, and copy number status of miR-137 and its host gene MIR137HG were assessed by polymerase chain reaction. Luciferase reporter assays confirmed a direct interaction between miR-137 and Y-box binding protein 1 gene…
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Medical study · Medical research · 2023
The association of genetic factors with serum calretinin levels in asbestos-related diseases
…genotyped for seven polymorphisms in CALB2, E2F2, MIR335, NRF1 and SEPTIN7 genes using competitive allele-specific polymerase chain reaction (PCR). Serum calretinin was determined with ELISA in 545 subjects. Nonparametric tests, logistic regression and receiver operating…