561 results for “Reaction Department”, page 19 of 29
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Medical study · Medical research · 2013
miR-1 induces growth arrest and apoptosis in malignant mesothelioma
…comparators. To confirm microarray data, we used real-time quantitative polymerase chain reaction. Representative cell lines H513 and H2052 were used in functional analyses of miR-1. In addition to several novel MPM-associated microRNAs, we…
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Medical study · Medical research · 2011
Epidermal growth factor receptor overexpression in malignant pleural mesothelioma: prognostic correlations
…status. Results were correlated with clinico-pathological characteristics and long-term survival. Thirty-eight cases (46%) demonstrated a positive IHC reaction [30/57 (52%) epithelial and 8/20 (40%) biphasic whereas sarcomatous MPM were negative]. No…
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Medical study · Medical research · 1994
Asbestos fibers and interferon-gamma up-regulate nitric oxide production in rat alveolar macrophages
…in macrophage conditioned medium, was assayed by the Griess reaction. Production of NO2- by AM was significantly increased by both chrysotile (P < 0.01) and crocidolite (P < 0.05) asbestos fibers (10 micrograms/ml…
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Medical study · Medical research · 1985
Pulmonary response of hamsters to fibrous glass: chronic effects of repeated intratracheal instillation with or without benzo[a]pyrene
…tumours might be that repeated administration of fibres over a period of 52 weeks entails an acute pulmonary reaction after each administration with the implication that the fibres cannot settle down well enough to be able…
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Medical study · Medical research · 1996
A study of the synergistic interaction of asbestos fibers with cigarette tar extracts for the generation of hydroxyl radicals in aqueous buffer solution
…This enhancement progressed with time, probably due to the reaction of the extracted iron with the slow released hydrogen peroxide from tar extracts. It was observed a fivefold increase in the ESR signal (for crocidolite and…
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Medical study · Medical research · 1993
Asbestos directly increases lung epithelial permeability
…and humans exposed to asbestos. It is not known whether the increased epithelial permeability results from direct effects of asbestos or occurs as a result of the inflammatory reaction to asbestos fibers. To address this question…
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Medical study · Medical research · 2010
Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma
…We also analyzed WIF-1 and SFRPs promoter methylations in 46 mesothelioma tissues, 8 mesothelioma cell lines by methylation-specific polymerase chain reaction (MSP). WIF-1 promoter methylation was observed in 34 of 46 mesothelioma tissues…
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Medical study · Medical research · 2019
Proton Beam Therapy and Immune Checkpoint Inhibitors in Malignant Pleural Mesothelioma
…and a biopsy showed alveolar injury. Corticosteroids led to rapid symptom resolution. The authors hypothesized that proton therapy caused immune "priming" and a later "recall" reaction. They concluded that the combination, particularly with very large treatment…
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Medical study · Medical research · 2018
Lung injury and expression of p53 and p16 in Wistar rats induced by respirable chrysotile fiber dust from four primary areas of China
…was calculated. Pathological changes in lung tissues were observed by optical microscope after the HE staining of tissues, and the gene expression of p53 and p16 was determined by reverse transcription polymerase chain reaction. First, the…
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Medical study · Medical research · 2017
Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity
…mesotheliomas, and lung cancers. However, it showed low reaction with normal cell lines such as lymphatic endothelial and renal epithelial cells. Moreover, chLpMab-2 exhibited high antibody-dependent cellular cytotoxicity (ADCC) against PDPN-expressing cells, despite…
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Medical study · Medical research · 2023
Microbe-Mineral Interactions between Asbestos and Thermophilic Chemolithoautotrophic Anaerobes
…structure of the asbestos mineral fibers. Further constraints on the relationships between elemental release rates, amount of starting asbestos, reaction volumes, and incubation times will be required to better compare asbestos dissolution treatments studied to date.
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Medical study · Medical research · 2023
The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples
…healthy Italian individuals contained in the 1000 genomes database were considered for comparison. PCR-multiplex amplification followed by SNaPshot mini-sequencing reaction was used. The findings presented in this study show that the allelic and genotypic…
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Medical study · Medical research · 2018
Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service
…hypersensitivity reactions are commonly encountered. The allergic clinical symptoms are variable and unpredictable. The aim of this study was to identify the characteristics of hypersensitivity reactions and to assess the value of skin tests for platinum…
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Medical study · Medical research · 2021
Phase 2 Study of YS110, a Recombinant Humanized Anti-CD26 Monoclonal Antibody, in Japanese Patients With Advanced Malignant Pleural Mesothelioma
…survival was 9.7 months. A total of 30 patients (96.8%) had at least one adverse event. Common treatment-related adverse events were infusion-related reaction (16.1%), hiccups (9.7%), and interstitial lung disease…
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Medical study · Medical research · 2021
Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors
…kg was selected as the recommended phase II dose. Seven patients (12%) reported infusion-related reactions. Treatment-related grade ≥3 treatment-emergent adverse events were pericardial effusion, colitis, infusion-related reaction, and pleural effusion (n=1 each…
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Medical study · Medical research · 2015
Metagenomic analysis reveals that modern microbialites and polar microbial mats have similar taxonomic and functional potential
…metabolism and iron cycling. Compared to the sediments, the microbialite microbiome has significantly more genes associated with photosynthetic processes (e.g., photosystem II reaction centers, carotenoid, and chlorophyll biosynthesis) and carbon fixation (e.g., CO dehydrogenase)…
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Medical study · Medical research · 2017
Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy
…The method used is appropriate for analyzing problems over complicated domains, such as when the domain changes (as in a solid-state reaction with a moving boundary), when the desired precision varies over the entire domain…
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Medical study · Medical research · 2017
Assessment of the potential respiratory hazard of volcanic ash from future Icelandic eruptions: a study of archived basaltic to rhyolitic ash samples
…worldwide. All samples generated a low level of hydroxyl radicals (HO•), a measure of surface reactivity, through the iron-catalyzed Fenton reaction compared to concurrently analyzed comparative samples. However, radical generation increased after 'refreshing' sample surfaces…
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Medical study · Medical research · 2020
Emerging indoor pollutants
…once again forming the focus of attention as re-emerging chemicals. Many relevant compounds, in particular reaction products, were unknown until recently due to the fact, that they can only now be detected using highly sensitive…
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Medical study · Medical research · 2019
Man-made mineral fiber effects on the expression of anti-oncogenes P53 and P16 and oncogenes C-JUN and C-FOS in the lung tissue of Wistar rats
…C-JUN, and C-FOS mRNA and protein were measured by quantitative real-time reverse transcription polymerase chain reaction and Western blotting. This work found that exposure to MMMFs could influence the growth of body mass…