561 results for “Reaction Department”, page 23 of 29
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Medical study · Medical research · 2019
Treatment status and safety of crizotinib in 2028 Japanese patients with ALK-positive NSCLC in clinical settings
…included 2028 Japanese patients, and more than half of the patients (56.4%) were nonsmokers. The incidence of adverse drug reactions (ADRs) was 91.6%, and common ADRs (incidence ≥15%) were nausea (32.2%), diarrhea (24…
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Medical study · Medical research · 2019
Phase I study of YS110, a recombinant humanized monoclonal antibody to CD26, in Japanese patients with advanced malignant pleural mesothelioma
…toxicity. Corticosteroid, antihistamine, and acetaminophen administration before each infusion was adopted to limit infusion-related reactions (IRRs). Nine Japanese patients (seven men and two women, mean age of 62.2 years), three in each dosing cohort…
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Medical study · Medical research · 2020
A Phase II Study of Pazopanib in Patients with Malignant Pleural Mesothelioma: NCCTG N0623 (Alliance)
…had no earlier chemotherapy and 15 had received a pemetrexed-containing regimen. The main goal was the share alive and progression-free at 6 months without having stopped treatment for adverse reactions, refusal or other therapy…
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Medical study · Medical research · 1983
An investigation of the penetration of ingested asbestos into the normal and abnormal intestinal mucosa of the rat
…surviving amosite-injected rat, the injection sites showed granulomas: dense masses of macrophages holding crystals that looked like amosite under polarized light. The saline rat showed smaller reactions of a different kind. Second, five healthy rats…
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Medical study · Medical research · 2004
H2-rich fluids from serpentinization: geochemical and biotic implications
…or health outcomes were studied. Chrysotile was treated only as a mineral: as a component in the modeled reactions and as a form of serpentine that grows in rock pore space. The calculations assumed a fluid…
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Medical study · Medical research · 2013
Nanomedicine: experts state safety concerns regarding carbon nanotubes have been allayed by chemistry
…nanotubes were completely removed when chemical treatment changed the nanotube surface and shortened the tubes. The study looked at two chemical reactions. The item said the paper concluded that only treatments that kept the nanotubes stable…
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Medical study · Medical research · 2013
Rare pleural tumors
…citing other reports. It also noted that asbestos-related pleural plaques, rounded atelectasis and inflammatory asbestos reactions can look like tumors on scans. The authors concluded that diagnosis rests on imaging, tissue samples and laboratory testing…
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Medical study · Medical research · 1977
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity
…Cape crocidolite and amosite. On skin tests, reactions to tuberculin did not differ significantly between the groups. Five of 26 patients and no controls failed to react to Candida extract. Fourteen of 26 patients and 6…
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Medical study · Medical research · 2000
Serologic responses in patients with malignant mesothelioma: evidence for both public and private specificities
…protein. Antibodies to topoisomerase II beta were found in 13 of 14 patients and in 6 of 16 volunteers, though the volunteers' reactions were generally weak. Antibodies to U2AF(65) were found in two patients. Each…
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Medical study · Medical research · 2016
Utility of BAP1 Immunohistochemistry and p16 (CDKN2A) FISH in the Diagnosis of Malignant Mesothelioma in Effusion Cytology Specimens
…might also be useful in effusion cytology specimens, we examined 15 biopsies of epithelial mesotheliomas and 3 benign mesothelial reactions and corresponding effusion cytology paraffin-embedded cell blocks. Four cytology specimens were too scanty for p16…
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Medical study · Medical research · 2014
Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma
…in the two arms, aside from infusion reactions which occurred in 70% of patients treated with CBP501. While this randomized phase II trial met its primary endpoint of PFS at 4 months, other parameters such as…
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Medical study · Medical research · 2012
Safety and effectiveness of pemetrexed in patients with malignant pleural mesothelioma based on all-case drug-registry study
…asbestos exposure, and 8.3% had asbestosis as judged by the prescribing physician. Adverse drug reactions were reported in 84.2% of patients, and seven deaths (0.8%) were possibly associated with the chemotherapy. Interstitial lung…
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Medical study · Medical research · 2016
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification
…Citing other studies, the authors described tests that showed promise but needed further confirmation. These included p16 FISH and BAP1 staining for separating mesothelioma from benign reactions, though neither finds every mesothelioma. They included a preliminary…
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Medical study · Medical research · 2011
Toxicity evaluations of various carbon nanomaterials
…toxicity because of their shape. One reviewed study reported that MWCNTs instilled into rats' airways remained in the lungs after 60 days and caused inflammation, fibrotic reactions and granulomas, similar to chrysotile. Another found that long…
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Medical study · Medical research · 2011
Morphological and chemical mechanisms of elongated mineral particle toxicities
…may cause disease. They discussed how particle size affects lung clearance and movement elsewhere, how surface area relates to reactions with cells, and iron chemistry in several minerals. Reviewed findings included that asbestos fibers can generate…
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Medical study · Medical research · 2010
WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
…lung cancer were vaccinated, and 10 could be evaluated for immune response. Seven of the 12 had mild (grade 1) injection-site reactions; no other side effects attributable to the vaccine were noted. Six of nine…
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Medical study · Medical research · 2004
Asbestos and the pleura: a review
…in pleural disease, laboratory research on how asbestos damages cells, and United States public policy. They described four benign pleural reactions (effusions, circumscribed plaques, diffuse pleural thickening and rounded atelectasis) as well as mesothelioma. Citing other…
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Medical study · Medical research · 2014
Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis
…compared with about 600 days for crocidolite and amosite. Nitrilotriacetic acid, a chemical that promotes iron-driven reactions, significantly promoted tumor development for all three fibers. Homozygous deletion (complete loss) of the Cdkn2a/2b tumor-suppressor…
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Medical study · Medical research · 2004
Pathogenesis of the eosinophilic pleural effusions
…pulmonary emboli, asbestos exposure, and drug reactions. Differences in the clinical features suggest that a variety of mechanisms operate to induce eosinophilic pleural inflammation and pleural fluid accumulation. Human and animal studies indicate that interleukin (IL…
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Medical study · Medical research · 1992
The role of free radicals in asbestos-induced diseases
…this reactive radical. However, asbestos also appears to catalyze electron transfer reactions that do not require iron. Iron chelators either inhibit or augment asbestos-catalyzed generation of the hydroxyl radical and/or pathological changes, depending on…