8 results for “Reaction Department”
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Medical study · Medical research · 1983
Reaction of mineral dusts with primary lung fibroblast cultures
This laboratory study, which also reviewed the authors' earlier work, tested nine mineral dusts on rabbit lung fibroblast cultures (collagen-making cells). Single doses of 10 to 1000 µg per culture were added on day 3. DNA and cell-layer collagen…
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Medical study · Medical research · 1984
Pulmonary toxicology of silica, coal and asbestos
…the air sacs and fibrotic nodules failed to develop. The author argued that the simple lung lesion of coal workers is best seen as a nonspecific reaction to heavy dust accumulation. In red-blood-cell tests…
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Medical study · Medical research · 1983
Transmigration of ingested asbestos
…with crystals resembling amosite visible inside cells. Saline injected into two control rats caused a smaller reaction. Rats given 100 mg of amosite by stomach tube daily for 5 days showed no macrophage response or other…
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Medical study · Medical research · 1983
Effects of chrysotile on a lysosomal enzyme preparation and on the hydrolytic enzyme activity of cultured alveolar macrophages
…inhibit or enhance lysosomal enzyme activity at either pH but may preferentially absorb specific enzymes and that the binding reaction between any given enzyme and mineral can be dependent on the presence of other organic compounds…
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Medical study · Medical research · 1983
Interactions of chrysotile asbestos with erythrocyte membranes
…cells and bind to cell membranes which may become wrapped around the fibers. This reaction is prevented by pretreatment of the cells with neuraminidase. The distribution of lectins which bind to membrane glycoproteins is altered by…
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Medical study · Medical research · 1983
Effect of intrabronchially instilled amosite on lavagable lung and pleural cells
…the study. No pleural reaction was seen in the saline instilled group. The inflammatory reactions indicated by the composition of the lavaged cells of the lung represent the in vivo toxicity of intrabronchially instilled amosite. The…
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Medical study · Medical research · 1983
Effect of asbestos on the metabolism of vasoactive substances in isolated perfused guinea pig lungs
…The tissue response consisted of both inflammatory reaction of terminal and respiratory bronchioles and diffuse alveolar septal infiltration with interstitial fibrosis. The reaction was characterized at six months by a progressive bronchiolitis obliterans with fibroblastic proliferation…
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Medical study · Medical research · 1983
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins
…significantly increased in both low and high dose groups. These changes in protein and lipid components of BAL following asbestos exposure constitute early indices of lung inflammatory reactions which may contribute to the development of asbestosis.