7 results for “Reaction Department”
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Medical study · Medical research · 1983
Acute lung response to amosite asbestos: a morphological study
This was an animal experiment in guinea pigs. It examined the lung's reaction during the week after amosite asbestos was placed in the windpipe. Exposed animals received 17.5 mg of ground commercial-grade amosite…
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Medical study · Medical research · 1985
Pathologic changes in the small airways of the guinea pig after amosite asbestos exposure
… where these fibers penetrated the airway walls, an interstitial inflammatory and fibrotic reaction (asbestosis) occurred. It is concluded that 1) amosite asbestos produces diffuse abnormalities throughout the noncartilagenous airways and possibly the cartilagenous airways as well…
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Medical study · Medical research · 1983
Effect of intrabronchially instilled amosite on lavagable lung and pleural cells
…the study. No pleural reaction was seen in the saline instilled group. The inflammatory reactions indicated by the composition of the lavaged cells of the lung represent the in vivo toxicity of intrabronchially instilled amosite. The…
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Medical study · Medical research · 1984
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
…hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos…
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Medical study · Medical research · 1989
Lung cell reactions in guinea pigs after inhalation of asbestos (amosite)
…blood vessels and in connection with the bronchioles. The data suggest that amosite at low doses ultimately causes fibrosis with a reaction pattern different from that seen in silicosis. The inflammation and fibrosis seems to develop…
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Medical study · Medical research · 1986
Studies on the role of oxygen radicals in asbestos-induced cytopathology of cultured human lung mesothelial cells
…after exposure to amosite asbestos, although oxygen radicals were readily detected in cells exposed to menadione, an uncoupler of oxidation-reduction reactions. Cellular thiol levels were reduced after exposure to menadione, but were not affected by…
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Medical study · Medical research · 1981
Comparative pulmonary responses to inhaled inorganic fibers with asbestos and fiberglass
…rats and hamsters but not in guinea pigs. Fine fiberglass particles were not fibrogenic. Rats revealed more fibrogenic pulmonary reactions than guinea pigs or hamsters. A few pulmonary tumors developed in animals exposed to asbestos, Fybex…