14 results for “Reaction Department”
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Medical study · Medical research · 1983
Reaction of mineral dusts with primary lung fibroblast cultures
This laboratory study, which also reviewed the authors' earlier work, tested nine mineral dusts on rabbit lung fibroblast cultures (collagen-making cells). Single doses of 10 to 1000 µg per culture were added on day 3. DNA and cell-layer collagen…
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Medical study · Medical research · 1984
Fiber localization and its relationship to lung reaction in rats after chronic inhalation of chrysotile asbestos
…with histologic changes indicating marked epithelial injury. Increased amounts of fibers are also localized in the lung interstitium with continued exposure to asbestos and are associated with a progressive interstitial fibrotic reaction. Following cessation of exposure…
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Medical study · Medical research · 1988
Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos
…this would be the most likely site of a significant cellular or fibrotic reaction. The characteristics and progression of tissue reactions occurring at first alveolar duct bifurcations after a single brief asbestos exposure was defined using…
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Medical study · Medical research · 1988
Formation of 8-hydroxydeoxyguanosine by asbestos and man made mineral fibres
…were compared with chrysotile fibres for their capacity to hydroxylate 2-deoxyguanosine to 8-hydroxydeoxyguanosine, a reaction that is mediated by formation of hydroxyl radicals. All three fibres produced 8-hydroxydeoxyguanosine in the absence of H2O2…
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Medical study · Medical research · 1983
Small-airway lesions in patients exposed to nonasbestos mineral dusts
…which they call mineral dust airways disease, is a nonspecific reaction of the small airways to inorganic particulates. The presence of such changes casts considerable doubt on the theory that small-airway abnormalities in asbestos workers…
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Medical study · Medical research · 1983
A murine model of asbestosis
…an initial macrophage reaction was found to progress to "asbestos body" formation and diffuse focal interstitial fibrosis within 1 year of a chronic exposure period. This reaction was most intense in areas adjacent to respiratory bronchioles…
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Medical study · Medical research · 1983
Effects of chrysotile on a lysosomal enzyme preparation and on the hydrolytic enzyme activity of cultured alveolar macrophages
…inhibit or enhance lysosomal enzyme activity at either pH but may preferentially absorb specific enzymes and that the binding reaction between any given enzyme and mineral can be dependent on the presence of other organic compounds…
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Medical study · Medical research · 1983
Interactions of chrysotile asbestos with erythrocyte membranes
…cells and bind to cell membranes which may become wrapped around the fibers. This reaction is prevented by pretreatment of the cells with neuraminidase. The distribution of lectins which bind to membrane glycoproteins is altered by…
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Medical study · Medical research · 1987
The stimulatory effects of asbestos on NADPH-dependent lipid peroxidation in rat liver microsomes
…It is not inhibited by superoxide dismutase, catalase and mannitol, indicating that oxygen radicals are not involved in the reaction. It is also not inhibited by desferrioxamine, indicating that it is not due to a release…
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Medical study · Medical research · 1985
An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats
…structure, and surface charge, the lung tissue reaction differed considerably. Lungs of animals exposed to UICC chrysotile B showed significant pathological alterations as early as 7 days following treatment. The lesions were localized in and around…
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Medical study · Medical research · 1984
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
…hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos…
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Medical study · Medical research · 1989
Rat lung reactivity to natural and man-made fibrous silicates following short-term exposure
…more significantly to attapulgite and Fiberfrax although the tissue reaction differed considerably for these two materials. While attapulgite, at doses up to 10 mg caused minimal reactions characterized by mononuclear cell infiltration mainly in the alveolar…
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Medical study · Medical research · 1987
The lung biological activity of American attapulgite
…not an inert material for lung tissue; it does produce a macrophagic and neutrophilic alveolitis in the early inflammatory phase of lung reaction with peribronchiolar involvement in some sheep. Whether or not this initial attapulgite induced…
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Medical study · Medical research · 1985
Selective exposure and analysis of the sheep tracheal lobe as a model for toxicological studies of respirable particles
…at Day 1) and only macrophages after; lung histology documented an early macrophagic alveolitis which decreased to less than 10% of the initial inflammatory reaction at Day 60, without other distortion of the lung and airway…