7 results for “General Electric”
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Medical study · Medical research · 1994
Chrysotile biopersistence in the lungs of persons in the general population and exposed workers
…form, with both fibers and fibrils > 5 microns in length. Comparison of the lung fiber content of occupationally exposed persons with that of the general population showed marked qualitative and quantitative differences. Fibers are durable…
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Medical study · Medical research · 1990
Human disease consequences of fiber exposures: a review of human lung pathology and fiber burden data
…medians, except one study reporting only a mean), extremely high compared with general-population background levels. The reviewed studies indicated that mesothelioma may occur with fiber burdens considerably lower than those needed to produce asbestosis. One…
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Medical study · Medical research · 1997
Efflux of reduced glutathione after exposure of human lung epithelial cells to crocidolite asbestos
…hour in that medium, so the authors suggested it was released from the cells continuously. They found no sign of general membrane damage. Activity of the enzyme gamma glutamylcysteine synthetase fell by 47%, while four other…
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Medical study · Medical research · 1997
Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis
…effective. Therefore, a key to reducing the mortality rate of this neoplasm is knowledge of the general sequence of genetic events between initiation of mesothelial cells and the emergence of the metastatic tumor cells. Unfortunately, relatively…
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Medical study · Medical research · 1990
Modulating factors in the expression of radiation-induced oncogenic transformation
…scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitative are also the least relevant in terms of human carcinogenesis and human risk estimation…
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Medical study · Medical research · 1997
Dose-response relationship of fibrous dusts in intraperitoneal studies
…90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action…
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Medical study · Medical research · 1997
Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose
…end of a subchronic study. However, there is no general agreement about quantification of these end points to define the MTD. To determine whether pulmonary responses are indicative of the MTD, we suggest defining an MTD…