145 results for “Reaction Department”, page 2 of 8
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Medical study · Medical research · 1996
Distinctive profile of alveolar macrophage-derived cytokine release induced by fibrogenic and nonfibrogenic mineral dusts
…BAL) for BAL cell populations and cytokine production in conjunction with histopathological assessment of lung tissue. Chrysotile B and short 4T30 chrysotile fibers induced chronic inflammatory reactions characterized by alveolar macrophage (AM) accumulation that resulted, respectively…
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Medical study · Medical research · 1992
Immunohistochemical study of 158 lung carcinomas
…carcinomas. The marker CEA stained only 33% of small cell and 60% of large cell carcinomas, and eight (26%) poorly differentiated squamous cell carcinomas showed no reaction. EMA stained about 90% of all four tumour groups…
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Medical study · Medical research · 1993
Bidirectional modulation of TNF-alpha production by alveolar macrophages in asbestos-induced pulmonary fibrosis
…alpha mRNA in AMs. These data indicate that lower levels of TNF-alpha resulted from inhibition at the gene expression level and provide evidence for bidirectional modulation of TNF-alpha production by AMs during inflammatory reactions.
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Medical study · Medical research · 1996
Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue
…and three reactive pleurae, and amplified by the polymerase chain reaction (PCR) using the primer pairs used previously on fresh frozen tissues-namely, the SV primer set directed at the LTAg gene sequence unique to SV40…
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Medical study · Medical research · 1993
Radical oxidation reactions of the purine moiety of 2'-deoxyribonucleosides and DNA by iron-containing minerals
…was investigated by using a double experimental approach. One involved the electron spin resonance spin-trapping measurement of organic radicals obtained by the reaction of activated oxygen species, released upon incubation of the minerals in phosphate…
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Medical study · Medical research · 1995
Role of iron in the reactivity of mineral fibers
…chemical processes that implicate surface iron as a primary cause of toxicity are: free radical release, mobilization by chelators, iron-catalyzed reactions. Three kinds of solids are compared: (i) well-known toxic materials, for example asbestos…
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Medical study · Medical research · 1996
Chrysotile inhibits glutathione-dependent protection against the onset of lipid peroxidation in rat lung microsomes
…investigated in vitro in rat lung microsomes. Addition of 1 mM glutathione to the above reaction system containing microsomes supplemented with vitamin E (1 nmol/mg protein) reduced lipid peroxidation. Similar protection by glutathione could be…
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Medical study · Medical research · 1998
Antiradical and chelating effects in flavonoid protection against silica-induced cell injury
Quercetin, dihydroquercetin, and rutin are capable of scavenging superoxide anion (rate constants of the reaction with superoxide at pH 10 were 1.7 x 10(5), 1.5 x 10(5), and 0.5 x 10…
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Medical study · Medical research · 1990
Mesothelial proliferation due to asbestos and man-made fibres. Experimental studies on rat omentum
…in rats has proven to be an appropriate method controlling fibrogenicity and carcinogenicity of asbestos fibres and other fibrous dusts. We analyzed the reaction patterns of mesothelial cover layer to different natural mineral fibres (crocidolite, chrysotile…
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Company document · 1997
Owens Corning's Responses to Plaintiffs' Master Interrogatories in Greco v. A-Best Products (1997)
…the early 1940s (No. 25), and that in 1956 it asked Owens-Illinois about Kaylo's health effects and was told the 1955 Saranac study showed animals "could develop a mild asbestosis reaction" (Nos. 18, 25…
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Company document · Union Carbide documents · April 1992
Union Carbide Brownsville, Texas Facility Asbestos Emergency Cleanup Notifications and Disposal Cost Comparison (1991-1992)
…Guzman, Texas Air Control Board, notifying of emergency cleanup Site sketch of facility (butane storage spheres, reaction facilities, main office, laboratory and maintenance complex) Earlier notification form with removal contractor, transporter and disposal site pending Blank…
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Medical study · Medical research · 1998
SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma, and non-malignant pulmonary diseases
…tumours, and 33 non-malignant samples) and 38 additional samples distant from tumours were studied for the occurrence of SV40-like DNA sequences by polymerase chain reaction (PCR) amplification followed by hybridization with specific probes. Sequences…
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Medical study · Medical research · 1999
VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours
…cell lines, 54 MPM tumours and five normal pleural tissues. Expression levels for receptors and ligands were assessed by semiquantitative reverse transcriptase polymerase chain reaction analysis. Microvessels were highlighted by immunohistochemical staining for factor VIII. The…
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Medical study · Medical research · 1998
Pathogenesis of experimentally induced asbestos mesothelioma in rats
…and small cells covering spaces over the ribs. Inflammatory reaction and permanent pathological regenerative processes were observed in the mesothelium during 24 months after inoculation of asbestos fibres. Different lesions which we regarded as preneoplastic or…
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Medical study · Medical research · 1991
Human mononuclear phagocytes express the insulin-like growth factor-II/mannose-6-phosphate receptor
…AM lavaged from individuals with asbestos exposure or from normal volunteers. Using the polymerase chain reaction and reverse transcriptase to reverse-transcribe mRNA from mononuclear phagocytes, specific IGF-II/M6P receptor cDNA was amplified and detected…
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Medical study · Medical research · 1999
Assessment of hazardous dust exposure by BAL and induced sputum
…T-lymphocyte subsets were analyzed by flow-activated cell sorter, and messenger RNA (mRNA) was transcribed by reverse transcriptase-polymerase chain reaction. Mineralogic particles were analyzed by scanning electron microscopy and polarizing light microscopy and quantified…
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Medical study · Medical research · 1992
Evidence of a role for mesothelial cell-derived interleukin 8 in the pathogenesis of asbestos-induced pleurisy in rabbits
…generated a probe for rabbit IL-8 mRNA by amplifying cDNA prepared from stimulated pleural mesothelial cells using the polymerase chain reaction (PCR) and primers based on homologous sequences in human and sheep IL-8 cDNAs…
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Medical study · Medical research · 1997
Absence of p53 mutations in malignant mesotheliomas
…mesotheliomas. Thirteen malignant mesotheliomas collected over the preceding 12 yr and maintained in paraffin blocks were examined by polymerase chain reaction (PCR) followed by both single-strand conformation polymorphism (SSCP) and denaturing gradient-gel electrophoresis (DGGE)…
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Medical study · Medical research · 1994
Genetic polymorphism for glutathione-S-transferase mu in asbestos cement workers
…findings, and lung function. Venous blood samples were obtained for the analysis of GSTM1 polymorphism by the polymerase chain reaction technique. Chest x ray films were classified according to the International Labour Organisation (ILO) 1980 classification…
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Medical study · Medical research · 1998
Human mesotheliomas contain the simian virus-40 regulatory region and large tumor antigen DNA sequences
…40-induced hamster mesothelioma tumor H9A. Polymerase chain reaction primers were used to amplify various simian virus 40 large T-antigen regions including a 105-base pair amino terminus fragment, a 281-base pair carboxyl terminus…