145 results for “Reaction Department”, page 4 of 8
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Medical study · Medical research · 1994
An experimental approach to the evaluation of the biopersistence of respirable synthetic fibers and minerals
…initial evaluation of solubility and durability, they cannot simulate the dynamics of inhalation deposition and clearance and the subsequent systemic reaction to fibers and minerals that occurs in the animal. To evaluate the biopersistence of synthetic…
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Medical study · Medical research · 1994
Asbestos fibers and interferon-gamma up-regulate nitric oxide production in rat alveolar macrophages
…in macrophage conditioned medium, was assayed by the Griess reaction. Production of NO2- by AM was significantly increased by both chrysotile (P < 0.01) and crocidolite (P < 0.05) asbestos fibers (10 micrograms/ml…
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Medical study · Medical research · 1996
A study of the synergistic interaction of asbestos fibers with cigarette tar extracts for the generation of hydroxyl radicals in aqueous buffer solution
…This enhancement progressed with time, probably due to the reaction of the extracted iron with the slow released hydrogen peroxide from tar extracts. It was observed a fivefold increase in the ESR signal (for crocidolite and…
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Medical study · Medical research · 1993
Asbestos directly increases lung epithelial permeability
…and humans exposed to asbestos. It is not known whether the increased epithelial permeability results from direct effects of asbestos or occurs as a result of the inflammatory reaction to asbestos fibers. To address this question…
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Court case · Maryland Court of Appeals · April 7, 1992 · in the opinion
Owens-Illinois, Inc. v. Armstrong (1992)
…may be detectable only on a microscopic or subclinical level. As a pathologist I define \disease' as the process of reaction and/or repair to injury. In the discussion which follows of the diseases of asbestosis…
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Court case · California Court of Appeal · April 30, 1996 · in the opinion
Armstrong World Industries v. Aetna Cas. & Sur. (1996)
…of Appeal, 1st Appellate Dist., 1st Div. 1996 - Goo… "This process — inhalation of asbestos fibers, the inflammatory reaction, and the resulting fibrosis — characterizes the disease asbestosis. When the fibrosis is extensive enough, i.e., when…
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Medical study · Medical research · 1998
Free radical activity of synthetic vitreous fibers: iron chelation inhibits hydroxyl radical generation by refractory ceramic fiber
…of salicylate. Presence of an iron chelator inhibited the ability of the RCF1 fibers to cause hydroxylation of salicylate, demonstrating that RCF1 generates hydroxyl radical by Fenton chemical reaction in the same way as amphibole asbestos.
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Medical study · Medical research · 1995
Free radical generation at the solid/liquid interface in iron containing minerals
…asbestos whereas the two oxides are mostly inert. Conversely magnetite turns out to be an excellent catalyst for hydrogen peroxide disproportionation while haematite is inactive also in this reaction. The results agree with the implication of…
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Medical study · Medical research · 1998
Phase I study of paclitaxel as a radiation sensitizer in the treatment of mesothelioma and non-small-cell lung cancer
…gastrointestinal (GI) toxicity (nausea and vomiting) was also observed at 120 mg/m2. Three of 30 patients developed a hypersensitivity reaction. Six patients had grade 2 lung injury manifested by a persistent cough that required antitussives…
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Medical study · Medical research · 1997
Pleural macrophage recruitment and activation in asbestos-induced pleural injury
…by scanning electron microscopy. Pleural macrophage supernatants were assayed for production of nitric oxide (NO) (by the Griess reaction) and tumor necrosis factor alpha (TNF-alpha) (by an enzyme-linked immunosorbent assay method). Significantly greater amounts…
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Medical study · Medical research · 1995
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California
…Los Angeles County). Samples of white blood cell DNA sufficient for determination of the GSTM1 genotype by a polymerase chain reaction-based assay were obtained from 342 case patients and 716 control subjects. The odds ratios…
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Medical study · Medical research · 1991
Contributions of experimental asbestosis in sheep to the understanding of asbestosis
…to 5 years. The authors described four tissue reactions to asbestos: no-retention, low-retention, high-retention and intermediate. They suggested that the intermediate reaction might explain non-progressive cases of minimal asbestosis. Exposure dose and…
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Medical study · Medical research · 1996
Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders
…= 24) or nonmalignant pulmonary disorders, such as asbestosis and/or pleural plaques (n = 52). Lymphocyte DNA and the polymerase chain reaction were used to determine the GSTM1, GSTT1, and NAT2 genotypes of the study…
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Medical study · Medical research · 1990
Unusual granular reactivity for carcinoembryonic antigen in malignant mesothelioma
…biopsies and three cell blocks from pleural effusions. Four tumours were epithelial and one was bimorphic. Immunoelectron microscopy in one case showed reaction product mainly associated with cytoplasmic vesicles, possibly Golgi-derived, and rough endoplasmic reticulum…
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Medical study · Medical research · 1996
Ber-EP4 for differentiating adenocarcinoma from reactive and neoplastic mesothelial cells in serous effusions. Comparison with carcinoembryonic antigen, B72.3 and Leu-M1
…diagnosis of serous effusions. It has the advantage of high sensitivity and ease of interpretation because of the high percentage of tumor cells stained, characteristic membranous staining and lack of cross-reaction with background inflammatory cells.
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Medical study · Medical research · 1998
Solitary fibrous tumor of the liver: a clinicopathologic and immunohistochemical study of nine cases
…field (hpf). Immunohistochemically, all the tumors showed a strong positive reaction against antibodies for CD-34 and vimentin. Follow-up information showed that two patients died within days of postsurgical resection of the tumor, whereas one…
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Medical study · Medical research · 1998
Exposure to carbon black: a cancer risk?
…tissues. It is therefore quite understandable that many researchers propose to interpret the changes observed in rat lung tissues after inhalation of carbon black as rat-specific reaction mechanisms that cannot be applied to human tissues…
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Medical study · Medical research · 1992
Biphasic lung diffusing capacity: detection of early asbestos induced changes in lung function
…choice in subjects with an isolated decrease in DLCO. Exposure to asbestos can be associated not only with a reduction in DLCO, but also with a temporary increase in DLCO caused by a subclinical inflammatory reaction.
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Medical study · Medical research · 1997
Short-term inhalation and in vitro tests as predictors of fiber pathogenicity
…and SiC. However, measurements of BrdU uptake into lung cells showed that amosite and SiC produced a greater reaction than code 100/475, which itself caused no more proliferation than that seen in untreated lungs. These…
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Medical study · Medical research · 1995
Radiological changes in asbestos cement workers
…exposure variables. Progression was found long after the end of exposure. The findings on costophrenic angle obliterations, supposed to be sequelae of benign pleural effusions, were consistent with an immediate reaction triggered by intense asbestos exposure.