1 result for “General Electric”
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Medical study · Medical research · 2018
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
…ADaptor (DEUBAD) domain to stimulate BAP1/Calypso DUB activity. Here we report that monoubiquitination of the DEUBAD is a general feature of ASXLs and Asx. BAP1 promotes DEUBAD monoubiquitination resulting in an increased stability of ASXL2…