226 results for “Reaction Department”, page 10 of 12
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Medical study · Medical research · 2019
Phase I study of YS110, a recombinant humanized monoclonal antibody to CD26, in Japanese patients with advanced malignant pleural mesothelioma
…toxicity. Corticosteroid, antihistamine, and acetaminophen administration before each infusion was adopted to limit infusion-related reactions (IRRs). Nine Japanese patients (seven men and two women, mean age of 62.2 years), three in each dosing cohort…
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Medical study · Medical research · 2013
Nanomedicine: experts state safety concerns regarding carbon nanotubes have been allayed by chemistry
…nanotubes were completely removed when chemical treatment changed the nanotube surface and shortened the tubes. The study looked at two chemical reactions. The item said the paper concluded that only treatments that kept the nanotubes stable…
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Medical study · Medical research · 2013
Rare pleural tumors
…citing other reports. It also noted that asbestos-related pleural plaques, rounded atelectasis and inflammatory asbestos reactions can look like tumors on scans. The authors concluded that diagnosis rests on imaging, tissue samples and laboratory testing…
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Medical study · Medical research · 2016
Utility of BAP1 Immunohistochemistry and p16 (CDKN2A) FISH in the Diagnosis of Malignant Mesothelioma in Effusion Cytology Specimens
…might also be useful in effusion cytology specimens, we examined 15 biopsies of epithelial mesotheliomas and 3 benign mesothelial reactions and corresponding effusion cytology paraffin-embedded cell blocks. Four cytology specimens were too scanty for p16…
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Medical study · Medical research · 2014
Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma
…in the two arms, aside from infusion reactions which occurred in 70% of patients treated with CBP501. While this randomized phase II trial met its primary endpoint of PFS at 4 months, other parameters such as…
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Medical study · Medical research · 2012
Safety and effectiveness of pemetrexed in patients with malignant pleural mesothelioma based on all-case drug-registry study
…asbestos exposure, and 8.3% had asbestosis as judged by the prescribing physician. Adverse drug reactions were reported in 84.2% of patients, and seven deaths (0.8%) were possibly associated with the chemotherapy. Interstitial lung…
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Medical study · Medical research · 2016
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification
…Citing other studies, the authors described tests that showed promise but needed further confirmation. These included p16 FISH and BAP1 staining for separating mesothelioma from benign reactions, though neither finds every mesothelioma. They included a preliminary…
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Medical study · Medical research · 2011
Toxicity evaluations of various carbon nanomaterials
…toxicity because of their shape. One reviewed study reported that MWCNTs instilled into rats' airways remained in the lungs after 60 days and caused inflammation, fibrotic reactions and granulomas, similar to chrysotile. Another found that long…
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Medical study · Medical research · 2011
Morphological and chemical mechanisms of elongated mineral particle toxicities
…may cause disease. They discussed how particle size affects lung clearance and movement elsewhere, how surface area relates to reactions with cells, and iron chemistry in several minerals. Reviewed findings included that asbestos fibers can generate…
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Medical study · Medical research · 2010
WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
…lung cancer were vaccinated, and 10 could be evaluated for immune response. Seven of the 12 had mild (grade 1) injection-site reactions; no other side effects attributable to the vaccine were noted. Six of nine…
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Medical study · Medical research · 2014
Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis
…compared with about 600 days for crocidolite and amosite. Nitrilotriacetic acid, a chemical that promotes iron-driven reactions, significantly promoted tumor development for all three fibers. Homozygous deletion (complete loss) of the Cdkn2a/2b tumor-suppressor…
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Medical study · Medical research · 2014
Quantification of short and long asbestos fibers to assess asbestos exposure: a review of fiber size toxicity
…per milliliter. Reviewed experiments found short fibers less active than long ones, though at high doses they could cause inflammation, lung fibrosis and pleural reactions. Reviewed human studies linked short, thin fibers with lung cancer, but…
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Medical study · Medical research · 2010
Use of exhaled breath condensate to investigate occupational lung diseases
…and asbestos-exposed workers, and at patients with silicosis. Other studies covered nine healthy people briefly exposed to toluene, people with asthmatic reactions to isocyanates, and patients with lung cancer. On asbestos, the review reported that…
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Court case · New Jersey Superior Court, Appellate Division · April 20, 2016
Seymoure v. AO Smith Water Products Company (2016)
…s counsel planned to use the records in other litigation, and the order set no limit on that. The court remanded for a protective order requiring redaction and limiting use to this case unless employees consent.
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Medical study · Medical research · 2014
Evidence of arsenic release promoted by disinfection by-products within drinking-water distribution systems
Changes in disinfectant type could trigger a cascade of reactions releasing pipe-anchored metals/metalloids into finished water. However, the effect of pre-formed disinfection by-products on the release of sorbed contaminants (arsenic-As in…
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Medical study · Medical research · 2017
Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats
…particles of micrometer length, such as carbon nanotubes, which have same dimensions as asbestos, are carcinogenic. Carcinogenicity of nanomaterials is strongly related to inflammatory reactions; however, the genotoxicity mechanism(s) is unclear. Indeed, inconsistent results on…
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Medical study · Medical research · 2017
The Lost City Hydrothermal Field: A Spectroscopic and Astrobiological Analogue for Nili Fossae, Mars
…temperature serpentinization is a critical process with respect to Earth's habitability and the Solar System. Exothermic serpentinization reactions commonly produce hydrogen as a direct by-product and typically produce short-chained organic compounds indirectly. Here…
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Medical study · Medical research · 2016
Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma
Pemetrexed, which is used for the treatment of non-small cell lung carcinoma and malignant mesothelioma, induces cutaneous adverse reactions in approximately 20% of patients. There are also reports of the induction of fibrosing disorders. We…
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Medical study · Medical research · 2019
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia
…and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO2, bicarbonate and H+. CA9…
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Medical study · Medical research · 2013
Pemetrexed-induced eyelid edema in lung cancer
…small cell lung cancer. Although pemetrexed is a safe drug, some adverse effects such as myelosupression and cutaneous reactions are observed. Pemetrexed-induced eyelid edema is a rare side effect of pemetrexed treatment, and until this…