226 results for “Reaction Department”, page 11 of 12
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Medical study · Medical research · 2013
Cytotoxicity induced by exposure to natural and synthetic tremolite asbestos: an in vitro pilot study
…the etiology of the pathological effects of asbestos, cellular reactions to natural and synthetic asbestos fibers were compared using a lung alveolar cancer cell line (A549 epithelial cells), considered the first target of inhaled micro-environmental…
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Medical study · Medical research · 2011
Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against human tumors with diverse origins
The T cell line HOZOT has a unique FOXP3+CD4+ CD8+CD25+ phenotype, exhibits suppressive activity in allogeneic mixed lymphocyte reactions (MLR), and produces IL-10, defining HOZOT as regulatory T cells (Tregs). Interestingly, in addition…
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Medical study · Medical research · 2013
Mantle wedge infiltrated with saline fluids from dehydration and decarbonation of subducting slab
…derived fluids play an important role in heat and material transfer in subduction zones. Dehydration and decarbonation reactions of minerals in the subducting slab have been investigated using phase equilibria and modeling of fluid flow. Nevertheless…
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Medical study · Medical research · 2015
A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor
…product development and potential risks on health. We investigated the difference of two different CNT and asbestos in inducing proinflammatory reactions in C57BL/6 mice after single pharyngeal aspiration exposure. We used long tangled and long…
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Medical study · Medical research · 2018
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes
…spraying, the rats were sacrificed for histological examination of the lung and chest wall; pleural cavity lavage was also collected at sacrifice for observation of pleural inflammatory reactions. The results indicated that intratracheally sprayed MWCNTs, like…
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Medical study · Medical research · 2019
The Effect of pH and Biogenic Ligands on the Weathering of Chrysotile Asbestos: The Pivotal Role of Tetrahedral Fe in Dissolution Kinetics and Radical Formation
…octahedra (Fe[6]), and FeIII substitutes Si tetrahedra (Fe[4]). Fe on fiber surfaces can generate hydroxyl radicals (HO. ) in Fenton reactions, which damage biomolecules. To better understand chrysotile weathering in soils, net Mg and Si…
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Medical study · Medical research · 2019
Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention
…caused by modern industrial development. The major pathogenic mechanisms include oxidative stress either via catalytic reactions against the asbestos surface or frustrated phagocytosis of macrophages, and specific adsorption of hemoglobin and histones by asbestos fibers in…
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Medical study · Medical research · 2012
Surface reactivity and cell responses to chrysotile asbestos nanofibers
…Alps. Electron microscopy, X-ray diffraction, and fluorescence spectroscopy revealed that the procedure does not affect mineralogical and chemical composition. Surface reactions related to oxidative stress, free radical generation, bioavailability of iron, and antioxidant depletion, revealed…
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Medical study · Medical research · 2014
Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice
…is little known about its effects on the immune system. We performed this study to determine whether erionite evokes autoimmune reactions in mice. Bone marrow derived macrophages (BMDM) were used to measure toxicity induced by erionite…
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Medical study · Medical research · 2013
Cyclooxygenase-2, epidermal growth factor receptor, and aromatase signaling in inflammation and mesothelioma
…asbestos fibers can cross the membrane barriers inside the body and cause inflammatory and fibrotic reactions. Such reactions are believed to be the mechanism by which asbestos fibers may trigger malignant mesothelioma in the pleural membrane…
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Medical study · Medical research · 2011
Non-neoplastic and neoplastic pleural endpoints following fiber exposure
…diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction…
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Medical study · Medical research · 2012
Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies
…of oxygen, a phenomenon referred to as the "Warburg effect", to counteract cancer cell growth. We have tested 3-bromopyruvate (3-BrPA), an inhibitor of pyruvate-associated reactions. Firstly, we tested this agent, in vitro, in…
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Medical study · Medical research · 2010
Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-pixe
…Ferrous iron, and Magnesium (the components of asbestos) deposition. These results indicate that the system could be useful for investigating the pathogenesis of inhaled particle-induced immune reactions and for determining harmful levels of exogenous agents.
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Medical study · Medical research · 2012
NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma
…similar incidence of malignant mesothelioma and survival times as wild-type mice. Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma. Notably…
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Medical study · Medical research · 2013
Crystal chemistry of the high temperature product of transformation of cement-asbestos
…for 15 min. After firing, they underwent a series of solid state reactions leading to global structural changes of the matrix. Effects of annealing time and temperature on the crystallization kinetics were thoroughly investigated. Both factors…
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Medical study · Medical research · 2014
Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms
…mesotheliomas or lung cancers. These are typical examples of inflammation-related carcinogenesis. It is apparent that the pathogens to induce inflammatory reactions in specific organs are not related to each other. However, the underlying pathogenesis in…
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Court case · U.S. Bankruptcy Court, Southern District of New York · September 8, 2010 · in the opinion
In re Quigley Company, Inc. (2010)
…evidence. Many contained the type of personal identifying information about the claimants that would be subject to redaction under Federal Bankruptcy Rule 9037 if filed with the Court. The Court directed the redaction of that information…
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Medical study · Medical research · 2016
Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice
…inhaled asbestos fibers; (2) the extent of the deposition of these ions is proportionally directly related and (3) iron and calcium deposition on inhaled asbestos fibers is concomitant with the appearance of inflammatory and hyperplastic reactions.
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Medical study · Medical research · 2014
Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes
…patchy parietal mesothelial proliferation lesions. In addition, MWCNT-L induced stronger inflammatory reactions including increased inflammatory cell number and cytokine/chemokine levels in the pleural cavity lavage than MWCNT-S. In contrast, MWCNT-S induced stronger…
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Medical study · Medical research · 2018
Inflammation and cancer
…As an example, oxidatively damaged transferrin released iron ion, which may mediate Fenton reactions and generate additional reactive oxygen species. Dysfunction of anti-oxidative proteins due to this damage might increase oxidative stress. Such damage in…