226 results for “Reaction Department”, page 3 of 12
-
Medical study · Medical research · 2013
Phase 2 study of sorafenib in malignant mesothelioma previously treated with platinum-containing chemotherapy
…at 8 weeks. The most common severe side effects were fatigue (15%), a hand-foot skin reaction called palmar-plantar erythrodysesthesia (13%) and rash (9%). Eleven patients (21%) stopped treatment because of side effects. PET scan…
-
Medical study · Medical research · 2011
Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia
…among other materials; and tropical pulmonary eosinophilia, caused by an immune reaction to filarial parasites. The review described earlier studies in which lung-wash (bronchoalveolar lavage) cells from patients with coal workers' pneumoconiosis, asbestosis and silicosis…
-
Medical study · Medical research · 2010
Pleural granuloma mimicking malignancy 42 years after slurry talc injection for primary spontaneous pneumothorax
…malignant cells or asbestos fibers. Keyhole surgery was converted to open surgery and the pleura was removed. The pathologist diagnosed chronic granulomatous pleuritis caused by a foreign body reaction, likely talc. Only on detailed questioning did…
-
Medical study · Medical research · 2010
Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?
…of treatment. The aim of this study was to determine the usefulness of skin tests in ruling out cross-reaction to cisplatin to continue platinum-based chemotherapy in patients who are responsive to these agents. Prick…
-
Medical study · Medical research · 2011
Auto-antibodies to β-F1-ATPase and vimentin in malignant mesothelioma
…against proteins from mesothelioma cell lines. They found no antibody reaction common to the patients. Serum from one patient strongly recognised proteins later identified as vimentin and the beta chain of ATP synthase (beta-F1-ATPase…
-
Medical study · Medical research · 2016
A regional approach for CAR T-cell therapy for mesothelioma: from mouse models to clinical trial
…at 196 days. In an earlier intravenous Phase I trial that included three MPM patients, all three developed antibodies and one had an anaphylactic reaction. The authors described their ongoing Phase I trial (NCT02414269), which gives…
-
Medical study · Medical research · 2016
Immune responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with particulate silica
…and NLR-C12, and the genes ASC and caspase-1 were significantly increased at certain time points. The authors concluded that NLR-C12 may be a candidate inflammasome sensor in the reaction triggered by particulate silica.
-
Medical study · Medical research · 2010
Collagen accumulation over time in the murine lung after exposure to crocidolite asbestos or Libby amphibole
…which the authors said would be unexpected so soon. The authors concluded that LA's fibrotic reaction did not reach crocidolite's level in the same period. They noted that the mouse model may imperfectly represent…
-
Medical study · Medical research · 2013
Melan A (A103) is not a marker of mesothelioma
…supplier (Lab Vision). The authors concluded that melan A (A103) is not expressed in mesotheliomas and that the earlier positive results most likely reflected a false-positive reaction of that antibody. The study did not examine…
-
Medical study · Medical research · 2010
Carbon nanotubes induce inflammation but decrease the production of reactive oxygen species in lung
…lungs and the elevation of proinflammatory cytokines in the plasma (Leptin and IL-6 at 6h) confirmed the induction of an inflammatory reaction. This inflammatory reaction was accompanied by a decrease in the local oxidative stress…
-
Medical study · Medical research · 2017
Malignant peritoneal mesothelioma and Crohn disease
Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The purpose…
-
Medical study · Medical research · 2013
Sources of organic nitrogen at the serpentinite-hosted Lost City hydrothermal field
The reaction of ultramafic rocks with water during serpentinization at moderate temperatures results in alkaline fluids with high concentrations of reduced chemical compounds such as hydrogen and methane. Such environments provide unique habitats for microbial communities…
-
Medical study · Medical research · 2012
Unusual DNA mismatch repair-deficient tumors in Lynch syndrome: a report of new cases and review of the literature
Immunohistochemical detection of DNA mismatch repair proteins and polymerase chain reaction detection of microsatellite instability have enhanced the recognition of mismatch repair-deficient neoplasms in patients with Lynch syndrome and, consequently, led to the identification of…
-
Medical study · Medical research · 2016
ACR Appropriateness Criteria Review ACR Appropriateness Criteria® Occupational Lung Diseases
Occupational lung disease is a category of disease entities characterized by a reaction of the lung parenchyma to inhaled aerosolized particles found in the environment. This document summarizes the imaging appropriateness data for silicosis, coal worker…
-
Medical study · Medical research · 2016
The Suppressed Induction of Human Mature Cytotoxic T Lymphocytes Caused by Asbestos Is Not due to Interleukin-2 Insufficiency
We previously reported that exposure to chrysotile B (CB) asbestos suppressed the induction of mature cytotoxic T lymphocytes (CTLs) during mixed lymphocyte reaction assays (MLRs) with a decrease in the proliferation of immature CTLs. However, the…
-
Medical study · Medical research · 2019
Chronic follicular pleuritis: a B cell-rich form of nonspecific pleuritis/fibrosis
…pleuritis/fibrosis (NSP) is rendered. The histology of this reaction has not been well described including a pattern of B cell lymphoid hyperplasia described as "chronic follicular pleuritis (CFP)". Thirty-two cases of NSP were studied…
-
Medical study · Medical research · 2016
SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma
…molecular targets for the development of more effective therapies for MPM. Using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and an RNA interference-based screening, we examined the SORORIN gene as potential therapeutic targets for…
-
Medical study · Medical research · 2018
Atmospheric Carbon Mineralization in an Industrial-Scale Chrysotile Mining Waste Pile
…ultramafic mining waste have the potential to be used as a safe and permanent sequestration solution for carbon dioxide (CO2). Our understanding of thermo-hydro-chemical regimes that govern this reaction at an industrial scale, however…
-
Medical study · Medical research · 2016
Microbially Accelerated Carbonate Mineral Precipitation as a Strategy for in Situ Carbon Sequestration and Rehabilitation of Asbestos Mine Sites
…stabilizing the tailings. Tailings were leached using sulfuric acid in reaction columns and subsequently inoculated with an alkalinity-generating cyanobacteria-dominated microbial consortium that was enriched from pit waters at the Woodsreef Mine. Leaching conditions that…
-
Medical study · Medical research · 2013
Strain differences in pleural mesothelial cell reactions induced by potassium octatitanate fibers (TISMO) infused directly into the thoracic cavity
Although we have previously reported that the fiber-shaped TISMO, morphologically similar to asbestos, can induce a severe mesothelial reaction in A/J mice, it is important to clarify any strain differences. In the present study…