226 results for “Reaction Department”, page 7 of 12
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Medical study · Medical research · 2011
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene
…repression of RAS proto-oncogene and the attenuation of MM tumor growth. The expression of miRNAs was determined by reverse transcription-quantitative polymerase chain reaction and in situ hybridization. RAS expression was determined by q-PCR…
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Medical study · Medical research · 2013
Metabolic response to pegylated arginine deiminase in mesothelioma with promoter methylation of argininosuccinate synthetase
…1 (ASS1). Immunohistochemistry showed his tumor was ASS1-deficient, and methylation-specific polymerase chain reaction confirmed ASS1 promoter methylation. He was randomly assigned to 320 IU/m2/wk of ADI-PEG20 by intramuscular injection. After 3…
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Medical study · Medical research · 2012
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells
…cells from 6TG and 5FU, consistent with the idea that adenine produced from the MTAP reaction competes with 6TG and 5FU for a rate limiting pool of phosphoribosyl-1-pyrophosphate (PRPP), which is required for the…
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Medical study · Medical research · 2013
No detection of simian virus 40 in malignant mesothelioma in Korea
…We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA. Of 62 total cases…
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Medical study · Medical research · 2014
Correlation between TS, MTHFR, and ERCC1 gene polymorphisms and the efficacy of platinum in combination with pemetrexed first-line chemotherapy in mesothelioma patients
…combination with pemetrexed or pemetrexed monotherapy were enrolled. Genomic DNA was isolated from peripheral blood. Using polymerase chain reaction and high resolution melt methods, the variable number of tandem repeat, the G>C single nucleotide polymorphism (SNP…
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Medical study · Medical research · 2012
Increased circulating miR-625-3p: a potential biomarker for patients with malignant pleural mesothelioma
…healthy controls. miRNAs with significantly different abundance between cases and controls were validated in a larger series of MM patients and in an independent series of MM patients using quantitative real-time polymerase chain reaction. Levels…
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Medical study · Medical research · 2014
Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma
…lines. Copy number analysis was measured by quantitative polymerase chain reaction and fluorescence in situ hybridization. Copy number analysis revealed copy number gains (CNGs) in chromosomal region 8q24 in six of 12 MPM cell lines. MicroRNA…
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Medical study · Medical research · 2013
miR-1 induces growth arrest and apoptosis in malignant mesothelioma
…comparators. To confirm microarray data, we used real-time quantitative polymerase chain reaction. Representative cell lines H513 and H2052 were used in functional analyses of miR-1. In addition to several novel MPM-associated microRNAs, we…
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Medical study · Medical research · 2011
Epidermal growth factor receptor overexpression in malignant pleural mesothelioma: prognostic correlations
…status. Results were correlated with clinico-pathological characteristics and long-term survival. Thirty-eight cases (46%) demonstrated a positive IHC reaction [30/57 (52%) epithelial and 8/20 (40%) biphasic whereas sarcomatous MPM were negative]. No…
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Medical study · Medical research · 2010
Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma
…We also analyzed WIF-1 and SFRPs promoter methylations in 46 mesothelioma tissues, 8 mesothelioma cell lines by methylation-specific polymerase chain reaction (MSP). WIF-1 promoter methylation was observed in 34 of 46 mesothelioma tissues…
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Court case · U.S. District Court, Eastern District of Pennsylvania · May 24, 2010 · in the opinion
Larson v. Georgia Pacific (In re Asbestos Products Liability Litigation, 2010)
… Deposition Pattern And Reaction Of Alveolar Epithelium And Pulmonary Macrophages," "Interstitial Accumulation Of Inhaled Chrysotile Asbestos Fibers And Consequent Formation of Microcalcifications," "Characterization Of Three Types Of Chrysotile Asbestos After Aerosolization," "Chrysotile Asbestos Inhalation Induces Tritiated…
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Medical study · Medical research · 2019
Proton Beam Therapy and Immune Checkpoint Inhibitors in Malignant Pleural Mesothelioma
…and a biopsy showed alveolar injury. Corticosteroids led to rapid symptom resolution. The authors hypothesized that proton therapy caused immune "priming" and a later "recall" reaction. They concluded that the combination, particularly with very large treatment…
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Medical study · Medical research · 2018
Lung injury and expression of p53 and p16 in Wistar rats induced by respirable chrysotile fiber dust from four primary areas of China
…was calculated. Pathological changes in lung tissues were observed by optical microscope after the HE staining of tissues, and the gene expression of p53 and p16 was determined by reverse transcription polymerase chain reaction. First, the…
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Medical study · Medical research · 2017
Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity
…mesotheliomas, and lung cancers. However, it showed low reaction with normal cell lines such as lymphatic endothelial and renal epithelial cells. Moreover, chLpMab-2 exhibited high antibody-dependent cellular cytotoxicity (ADCC) against PDPN-expressing cells, despite…
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Medical study · Medical research · 2018
Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service
…hypersensitivity reactions are commonly encountered. The allergic clinical symptoms are variable and unpredictable. The aim of this study was to identify the characteristics of hypersensitivity reactions and to assess the value of skin tests for platinum…
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Medical study · Medical research · 2015
Metagenomic analysis reveals that modern microbialites and polar microbial mats have similar taxonomic and functional potential
…metabolism and iron cycling. Compared to the sediments, the microbialite microbiome has significantly more genes associated with photosynthetic processes (e.g., photosystem II reaction centers, carotenoid, and chlorophyll biosynthesis) and carbon fixation (e.g., CO dehydrogenase)…
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Medical study · Medical research · 2017
Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy
…The method used is appropriate for analyzing problems over complicated domains, such as when the domain changes (as in a solid-state reaction with a moving boundary), when the desired precision varies over the entire domain…
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Medical study · Medical research · 2017
Assessment of the potential respiratory hazard of volcanic ash from future Icelandic eruptions: a study of archived basaltic to rhyolitic ash samples
…worldwide. All samples generated a low level of hydroxyl radicals (HO•), a measure of surface reactivity, through the iron-catalyzed Fenton reaction compared to concurrently analyzed comparative samples. However, radical generation increased after 'refreshing' sample surfaces…
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Medical study · Medical research · 2019
Man-made mineral fiber effects on the expression of anti-oncogenes P53 and P16 and oncogenes C-JUN and C-FOS in the lung tissue of Wistar rats
…C-JUN, and C-FOS mRNA and protein were measured by quantitative real-time reverse transcription polymerase chain reaction and Western blotting. This work found that exposure to MMMFs could influence the growth of body mass…
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Medical study · Medical research · 2018
Oxidative and cytotoxic stress induced by inorganic granular and fibrous particles
…the gene expression of X‑linked inhibitor of apoptosis (XIAP), superoxide dismutase (SOD)1 and SOD2 were analysed by reverse transcription‑quantitative polymerase chain reaction. All investigated granular particles induce ROS production in A549 lung carcinoma cells within…