48 results for “Reaction Department”, page 1 of 3
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Medical study · Medical research · 2017
Mesothelioid reaction following talc pleurodesis: a case report
…Such a mesothelioid reaction can clinically and radiographically mimic malignant mesothelioma. We conclude that Talc pleurodesis played a causative role in this patient developing an intense mesothelioid reaction. A mesothelioid reaction should be included in the…
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Medical study · Medical research · 2015
Disseminated Pleural Siliconoma Mimicking Malignant Pleural Mesothelioma
This case report from a thoracic surgery department in Ube, Japan, described one 48-year-old woman with multiple nodules on the lining of her left lung (the pleura). She had received silicone breast implants 10…
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Medical study · Medical research · 2012
Toxic epidermal necrolysis related to Cisplatin and pemetrexed for metastatic non-small cell lung cancer
Toxic epidermal necrolysis (TEN) is an uncommon but life-threatening adverse drug reaction. Pemetrexed is a multitargeted antifolate. It was first used in combination with cisplatin as a front-line treatment for malignant pleural mesothelioma. The…
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Medical study · Medical research · 2017
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors
Hypertrophic osteoarthropathy (HOA) is a rare paraneoplastic syndrome characterized by digital clubbing, periosteal reaction, polyarthralgia, arthritis, and synovitis. Herein, we report a case series of patients with secondary HOA caused by non-pleural or pulmonary tumors…
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Medical study · Medical research · 2016
BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas
…help diagnose sarcomatous and desmoplastic mesotheliomas. These tumors can be hard to distinguish from organizing pleuritis, a benign reaction of the pleura. The authors tested tissue from 20 such pleural mesotheliomas, from 18 men and 2…
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Medical study · Medical research · 2018
Pemetrexed-induced painful erythematous nodules in both legs in a patient with recurrent mesothelioma
…supported considering the reaction a drug-induced hypersensitivity. They reported her as the first patient described with such lesions while receiving pemetrexed for mesothelioma, adding a nodular form to the known skin reactions to this drug…
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Medical study · Medical research · 2017
CAR T-cell therapy for lung cancer and malignant pleural mesothelioma
…The review also described earlier studies. One was a University of Pennsylvania trial that treated four patients; one patient had a serious anaphylactic reaction. Others were the authors' own mouse experiments, in which giving mesothelin-targeted…
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Medical study · Medical research · 2013
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma
…micropapillary, and solid patterns. Initial diagnoses by referring pathologists included reactive changes (1), hypersensitivity pneumonitis versus drug reaction (1), desquamative interstitial pneumonia versus neoplasm (1), and mesothelioma (2). Microscopic pleural involvement was identified in 4 cases…
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Medical study · Medical research · 2013
Melan A (A103) is not a marker of mesothelioma
…supplier (Lab Vision). The authors concluded that melan A (A103) is not expressed in mesotheliomas and that the earlier positive results most likely reflected a false-positive reaction of that antibody. The study did not examine…
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Medical study · Medical research · 2017
Malignant peritoneal mesothelioma and Crohn disease
Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The purpose…
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Medical study · Medical research · 2016
SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma
…molecular targets for the development of more effective therapies for MPM. Using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and an RNA interference-based screening, we examined the SORORIN gene as potential therapeutic targets for…
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Medical study · Medical research · 2011
Is a single nucleotide polymorphism a risk factor for lung cancer in the matrix metalloproteinase-2 promoter?
…200 lung cancer patients + 100 no lung cancer) were analyzed. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism (RFLP) and electrophoresis. Plasma MMP-2 enzyme activity levels were measured by using ELISA…
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Medical study · Medical research · 2013
Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis
…examination is inconclusive. We studied the usefulness of deletion of p16 with fluorescence in situ hybridization (FISH) and p16 hypermethylation with polymerase chain reaction for the diagnosis and prognosis of malignant pleural mesothelioma (MPM). We analyzed…
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Medical study · Medical research · 2016
Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma
…protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3). Real time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to assess the steady-state levels of AM…
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Medical study · Medical research · 2016
Young investigator challenge: MicroRNA-21/MicroRNA-126 profiling as a novel tool for the diagnosis of malignant mesothelioma in pleural effusion cytology
…authors evaluated the utility of an miRNA-based classifier as a complement to cytology. Quantitative reverse transcriptase-polymerase chain reaction analysis of 15 miRNAs was performed in mesothelial (MET-5A) and MM (H28 and H2052) cell…
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Medical study · Medical research · 2016
Low homozygous/high heterozygous deletion status by p16 FISH correlates with a better prognostic group than high homozygous deletion status in malignant pleural mesothelioma
…FISH was performed in 93 MPMs and 47 RMHs. Real-time polymerase chain reaction (PCR) and methylation specific PCR (MSP) were also performed for cases in which DNA was available. Overall survival (OS) was assessed via…
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Medical study · Medical research · 2019
Clinical significance of serum DRAM1 mRNA, ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 axis expression in malignant pleural mesothelioma
…miR-2053) and long noncoding RNA ( lncRNA-RP1-86D1.3). Then, quantitative real-time polymerase chain reaction (qPCR) validation in sera of 60 MPM patients, 20 chronic asbestos exposure patients, and 20 healthy volunteers was done…
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Medical study · Medical research · 2018
BAP1 gene mutations in Egyptian patients with advanced sporadic malignant pleural mesothelioma (MPM): relation with clinical outcomes and survival
…and treated as advanced MPM. BAP1 gene mutations were assessed from circulating tumor cells (CTCs) by polymerase chain reaction (PCR) and sequencing and these mutations have been confirmed using the tumor tissue. BAP1 immunohistochemistry was performed…
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Medical study · Medical research · 2016
Histopathology of removed indwelling pleural catheters from patients with malignant pleural diseases
…the lumen of 11 IPCs (27%). A foreign body giant cell reaction was present at the cuff site in all the 29 IPC in which the subcutaneous cuff was examined. Acute (n = 10) and/or…
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Medical study · Medical research · 2016
Population pharmacokinetics and exposure-response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection
…models. Amatuximab PK was best described by a two-compartment model with parallel linear and nonlinear elimination pathways. Body weight and an antidrug antibodies reaction with the titer >64 affected volume of distribution and clearance, respectively…