71 results for “Reaction Department”, page 2 of 4
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Medical study · Medical research · 2021
UHRF1 Is a Novel Druggable Epigenetic Target in Malignant Pleural Mesothelioma
…in malignant pleural mesothelioma (MPM). This study was undertaken to explore the therapeutic potential of targeting UHRF1 in MPM. Microarray, real-time quantitative reverse transcription-polymerase chain reaction, immunoblot, and immunohistochemistry techniques were used to evaluate…
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Medical study · Medical research · 2020
LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma
…that could act as MPM biomarkers. We carried out additional molecular analyses of these potential markers using MPM patient tissue samples via quantitative polymerase chain reaction. We identified Lysyl oxidase (LOX), Lysyl oxidase homologs 1&2…
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Medical study · Medical research · 2024
Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases
…length was also determined in samples from MM patients before and after chemotherapy. Telomere length was determined by monochromatic multiplex quantitative polymerase chain reaction (PCR), while competitive allele-specific PCR was used to genotype hTERT rs10069690…
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Medical study · Medical research · 2021
Re-evaluating the pathogenicity of the c.783+2T>C BAP1 germline variant
…None of the three available tumors showed an allelic loss, there was no discernable effect on alternative splicing based on reverse-transcription polymerase chain reaction, and there was no decrease or loss of somatic protein expression…
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Medical study · Medical research · 2020
Attenuation of oxidative stress and chromosomal aberrations in cultured macrophages and pulmonary cells following self-sustained high temperature synthesis of asbestos
…However, there was an attenuation of redox status imbalance and an absence of chromosomal aberrations, which probably reflects the loss of the asbestos fibrous structure following SHS reaction, as demonstrated by electron microscopy analyses. In conclusions…
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Medical study · Medical research · 2020
Efficient separation of Zn(Ⅱ) from Cd(Ⅱ) in sulfate solution by mechanochemically activated serpentine
…in the presence of SO42-. By adjusting the parameters including grinding intensity, reaction temperature, serpentine dosage and salt species, the optimum conditions were determined and a 92% separation rate of Zn(Ⅱ) and Cd(Ⅱ) ions…
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Medical study · Medical research · 2020
Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes
…naïve CD8+ T cells following antigen stimulation. Exposure to chrysotile B asbestos suppressed the differentiation of CTLs during the mixed lymphocyte reaction (MLR) and was associated with a decrease in proliferation of CD8+ T cells. Additionally…
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Medical study · Medical research · 2020
Evaluation of soluble mesothelin-related peptides and MSLN genetic variability in asbestos-related diseases
…154 had MM. Serum SMRP levels were determined using sandwich enzyme-linked immunosorbent assay. All subjects were genotyped for MSLN rs1057147 polymorphism using competitive allele-specific polymerase chain reaction. Nonparametric tests, logistic and Cox regression were…
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Medical study · Medical research · 2020
Chrysotile asbestos treated with phosphoric acid as an adsorbent for ammonia nitrogen
…its use is banned for many applications. The idea was to obtain a compound that could immobilize phosphate by triggering a reaction between the magnesium oxide and hydroxide contained in the mineral, without causing phosphate leaching…
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Medical study · Medical research · 2021
Herpes Simplex Virus Meningoencephalitis Following Pulse-Dose Methylprednisolone: A Case Report and Literature Review
…days, the patient developed a fever and worsening encephalopathy. A lumbar puncture showed elevated nucleated cells and positive polymerase chain reaction for herpes simplex virus 1 in the cerebrospinal fluid, confirming the diagnosis of HSVE. Acyclovir…
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Medical study · Medical research · 2023
The association of genetic factors with serum calretinin levels in asbestos-related diseases
…genotyped for seven polymorphisms in CALB2, E2F2, MIR335, NRF1 and SEPTIN7 genes using competitive allele-specific polymerase chain reaction (PCR). Serum calretinin was determined with ELISA in 545 subjects. Nonparametric tests, logistic regression and receiver operating…
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Medical study · Medical research · 2024
Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma
…in cancer. This study aimed to identify potential biomarkers for PM diagnosis by investigating the expression of specific circRNA gene pattern (hsa_circ_0007386) in cells and sEVs using digital polymerase chain reaction (dPCR). For this…
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Medical study · Medical research · 2021
Programmed cell death 1 ligand 1 (PD-L1) expression is associated with poor prognosis of malignant pleural mesothelioma patients with good performance status
…expression in MPM prognosis. Biopsy samples from 198 patients diagnosed with MPM were examined by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) to evaluate PD-L1 protein and gene expression. For PD-L1…
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Medical study · Medical research · 2020
Medical Challenge Posed by Retroperitoneal Fibrosis: Case Reports and Literature Review
…tomography (CT) and magnetic resonance imaging (MRI) are the most reliable imaging modalities. The goal of treatment is to stop the progression of the fibroinflammatory reaction. The first line of treatment is usually with medical management…
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Medical study · Medical research · 2020
Induction of Gamma-Glutamyltransferase Activity and Consequent Pro-oxidant Reactions in Human Macrophages Exposed to Crocidolite Asbestos
…its fibers as well as to its content of iron. The latter can in fact react with macrophage-derived hydrogen peroxide in the so called Fenton reaction, giving rise to highly reactive and mutagenic hydroxyl radical…
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Medical study · Medical research · 2020
The role of endothelial nitric oxide synthase gene polymorphisms in patients with lung cancer
…Designated polymorphisms were identified by polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP). Our study showed that the frequencies of the b/b genotype and b allele of eNOS gene intron 4 VNTR…
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Blog · 2025
Asbestos Exposed: The Shocking Revelations from Saranac Labs, Part 2
…unknowingly shrouded in a deadly cloak of asbestos, the silent killer lying at the heart of industrial progress. Initial Revelations and The Industry’s Reaction In the early 1930s, the asbestos industry was already privy to…
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Blog · 2024
BBC Show Finds Asbestos Contaminating Old Makeup
…especially women, were unaware that they had been exposed to a time-bomb with a very long fuse.” This delayed reaction time complicates diagnosis and treatment, underscoring the critical need for stringent regulations to prevent exposure…
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Blog · 2022
Can Cats Be Harmed By Asbestos Exposure?
…fibers become embedded, they cause inflammation and instigate an immune response, setting off a chain reaction that leads to the growth of unnatural and potentially malignant cell mutations. When these mutations become cancerous, it is known…
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Blog · 2024
The Fin Bros Are Coming for Your Asbestos Claim
…Harbor As housing prices plummeted and defaults soared, these securities quickly became toxic, dragging down the banks that held them and triggering a chain reaction that brought the economy to its knees. The irony, of course…