9 results for “Owens-Illinois”
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Medical study · Medical research · 2021
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
This laboratory study did not involve asbestos or people with mesothelioma. It concerned uveal melanoma, an eye cancer, and the gene BAP1, which the authors note is also mutated in mesothelioma and other cancers. The authors looked for drugs that…
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Medical study · Medical research · 2021
Asbestos containing materials in schools of Rome and surrounding area (Italy)
…vinyl floor tiles. Forty also had friable ACM, such as boiler insulation, linings of laboratory ovens and centrifuges, and Bunsen burner gauze mats. Crocidolite with chrysotile was found in about 80% of roofing samples, and vinyl…
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Medical study · Medical research · 2020
Induction of Gamma-Glutamyltransferase Activity and Consequent Pro-oxidant Reactions in Human Macrophages Exposed to Crocidolite Asbestos
Asbestos is the main causative agent of malignant pleural mesothelioma. The variety known as crocidolite (blue asbestos) owns the highest pathogenic potential, due to the dimensions of its fibers as well as to its content of…
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Medical study · Medical research · 2021
Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
…of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.
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Medical study · Medical research · 2020
Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody-Drug Conjugate
…increased binding of AM1 to EGFR-positive tumor cells, opens the possibility to target a wide array of tumors beyond those with high levels of EGFR overexpression or amplification, including those insensitive to auristatin-based ADCs…
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Medical study · Medical research · 2021
Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques
…Fe content in the ABs was higher than that possibly contained in chrysotile and crocidolite. This finding opens two opposite scenarios, the first with Fe coming from the fiber bulk and concentrating on the surface as…
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Medical study · Medical research · 2020
A new trajectory approach for investigating the association between an environmental or occupational exposure over lifetime and the risk of chronic disease: Application to smoking, asbestos, and lung cancer
…dose and the timing of exposure. The proposed approach opens new perspectives for the analyses of dose-time-response relationships between protracted exposures and the risk of developing a chronic disease, by providing a complete picture…
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Medical study · Medical research · 2021
Pathological Characterization of Tumor Immune Microenvironment (TIME) in Malignant Pleural Mesothelioma
…a greater understanding of the pathogenetic mechanisms in tumor development and pathobiology of TIME, that opens the way to new therapeutic strategies. The study of TIME is fundamental in identifying appropriate prognostic and predictive tissue biomarkers…
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Medical study · Medical research · 2020
Inhibitors of cytoskeletal dynamics in malignant mesothelioma
…species. One of these, imipramine blue, was particularly effective in counteracting some key malignant properties of highly invasive MM cells. This opens a new possibility for targeted inhibition of MMs based on well-established molecular mechanisms.