18 results for “Reaction Department”
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Medical study · Medical research · 2020
Unusually favorable outcome of 6 consecutive patients with diffuse malignant peritoneal mesothelioma treated with repeated doses of intraperitoneal paclitaxel. A case series
…died of disease 15 years after treatment. Three of the 6 had a grade III/IV adverse event: an inverted and then infected port, an intense allergic reaction, and a small bowel perforation. In 5 patients…
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Medical study · Medical research · 2022
Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial
…193a-5p, also appeared in earlier mesothelioma data. Of 21 men who took AWPC, 11 reported at least one adverse reaction. None were considered serious. AWPC was suspected as the cause in 3 men, all of…
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Medical study · Medical research · 2020
Targeting ROR1 in combination with pemetrexed in malignant mesothelioma cells
…Microarray, quantitative polymerase chain reaction, and Western blot analyses showed that there were differences in the suppression of mRNA and proteins between H2452 and H28 cells transfected with siROR1 compared with those transfected with control siRNA…
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Medical study · Medical research · 2021
UHRF1 Is a Novel Druggable Epigenetic Target in Malignant Pleural Mesothelioma
…in malignant pleural mesothelioma (MPM). This study was undertaken to explore the therapeutic potential of targeting UHRF1 in MPM. Microarray, real-time quantitative reverse transcription-polymerase chain reaction, immunoblot, and immunohistochemistry techniques were used to evaluate…
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Medical study · Medical research · 2020
Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes
…naïve CD8+ T cells following antigen stimulation. Exposure to chrysotile B asbestos suppressed the differentiation of CTLs during the mixed lymphocyte reaction (MLR) and was associated with a decrease in proliferation of CD8+ T cells. Additionally…
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Medical study · Medical research · 2020
Evaluation of soluble mesothelin-related peptides and MSLN genetic variability in asbestos-related diseases
…154 had MM. Serum SMRP levels were determined using sandwich enzyme-linked immunosorbent assay. All subjects were genotyped for MSLN rs1057147 polymorphism using competitive allele-specific polymerase chain reaction. Nonparametric tests, logistic and Cox regression were…
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Medical study · Medical research · 2023
The association of genetic factors with serum calretinin levels in asbestos-related diseases
…genotyped for seven polymorphisms in CALB2, E2F2, MIR335, NRF1 and SEPTIN7 genes using competitive allele-specific polymerase chain reaction (PCR). Serum calretinin was determined with ELISA in 545 subjects. Nonparametric tests, logistic regression and receiver operating…
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Medical study · Medical research · 2024
Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma
…in cancer. This study aimed to identify potential biomarkers for PM diagnosis by investigating the expression of specific circRNA gene pattern (hsa_circ_0007386) in cells and sEVs using digital polymerase chain reaction (dPCR). For this…
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Medical study · Medical research · 2021
Programmed cell death 1 ligand 1 (PD-L1) expression is associated with poor prognosis of malignant pleural mesothelioma patients with good performance status
…expression in MPM prognosis. Biopsy samples from 198 patients diagnosed with MPM were examined by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) to evaluate PD-L1 protein and gene expression. For PD-L1…
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Medical study · Medical research · 2023
The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples
…healthy Italian individuals contained in the 1000 genomes database were considered for comparison. PCR-multiplex amplification followed by SNaPshot mini-sequencing reaction was used. The findings presented in this study show that the allelic and genotypic…
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Court case · Utah Supreme Court · November 18, 2021 · in the opinion
Boynton v. Kennecott Utah Copper, LLC (2021)
…and thereby injures another. In Jeffs, we found it foreseeable that negligently prescribing medications to a patient might result in the patient then injuring someone else in situations where the medications cause a psychotic reaction. Id. …
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Court case · Vermont Supreme Court · May 10, 2024 · in the opinion
Carpin v. Vermont Yankee Nuclear Power Corporation (2024)
…. mesothelioma." He also corroborated that exposure to "asbestos fibers set up an inflammatory reaction" that leads to the disease, but ultimately it is the "asbestos that the patient breathes that is the cause of the disease…
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Court case · New York Surrogate's Court · July 26, 2024
Matter of Lucano (2024)
…which caused mesothelioma and his death. The court said the requested redaction was really a request to seal court records, since the rules allow redaction only of limited confidential personal information. It held that sealing requires…
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Medical study · Medical research · 2020
A Phase II Study of Pazopanib in Patients with Malignant Pleural Mesothelioma: NCCTG N0623 (Alliance)
…had no earlier chemotherapy and 15 had received a pemetrexed-containing regimen. The main goal was the share alive and progression-free at 6 months without having stopped treatment for adverse reactions, refusal or other therapy…
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Medical study · Medical research · 2020
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma
…mg/kg and used for cohort expansion. The most common treatment-related adverse events (AEs) were nausea (56%), decreased appetite (36%), infusion reactions (36%), decreased neutrophil counts (36%), and fatigue (33%). The confirmed ORR was 39%…
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Court case · U.S. District Court, Northern District of Ohio · May 11, 2023 · in the opinion
Parker Hannifin Corp. v. Standard Motor Products, Inc. (2023)
…promptly meet and confer to determine what, if any, portions of this Memorandum Opinion & Order warrant redaction. By no later than fourteen (14) days from the date of this Order, the parties shall file a Joint…
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Court case · U.S. District Court, Eastern District of Louisiana · September 4, 2024 · in the opinion
Palermo v. Eagle Inc. (2024)
…the Court finds that this concern can be minimized by use of a protective order and exclusion/redaction of irrelevant financial and health records. The next factor is whether the information sought is factual data or…
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Court case · Washington Court of Appeals · February 12, 2024 · in the opinion
Cockrum v. Murphy (2024)
…headaches, and dizziness." Id. Boeing's general manager said "he knew these complaints were reactions to working with the phenolic material." Id. Birklid concluded that Boeing knew in advance its workers would become ill, yet put…