44 results for “Reaction Department”, page 1 of 3
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Medical study · Medical research · 2021
New-Onset Diabetes with Ketoacidosis Precipitated by COVID-19 in Children: A Report of Two Cases
…in the parents of the 2 children. An asymptomatic infection was detected in the 2 patients on the basis of a reverse transcription polymerase chain reaction (RT-PCR) test. Thoracic imaging and inflammatory workup were negative…
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Medical study · Medical research · 2023
Dissolution Reaction and Surface Modification of UICC Amosite in Mimicked Gamble's Solution: A Step towards Filling the Gap between Asbestos Toxicity and Its Crystal Chemical Features
This was a laboratory experiment on fibres, not a study of people. The authors placed 20 mg of UICC amosite asbestos (from the Penge mine, South Africa) in 40 mL of mimicked Gamble's solution, a simulated biological fluid, at pH 4.5 and 37 degrees…
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Medical study · Medical research · 2021
Role of unfolded proteins in lung disease
…reports no new data of its own. It describes research on endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), a cell's reaction to misfolded proteins, in lung disease. Reviewed triggers included cigarette smoke…
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Medical study · Medical research · 2022
Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review
…Chrysotile did not induce ANA, and erionite fibers did induce ANA. Crystalline silica produced a lupus-like reaction in autoimmune-prone mouse strains, but the evidence in healthy strains was less convincing. The authors rated 19…
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Medical study · Medical research · 2023
Synthesis of Ni-Doped Tremolite Fibers to Help Clarify the Aetiology of the Cytotoxic Outcome of Asbestos
…The experimental conditions (temperature, pressure, reaction time and water amount) were optimized to produce batches of asbestos fibers of the tremolite phase, with uniformly distributed shape and dimensions and a controlled content of Ni2+ metal ions.
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Medical study · Medical research · 2021
Intrapleural silicone granuloma mimicking pleural malignancy
…concerning for metastatic disease. Further workup with a core-needle biopsy of the pleural nodule revealed "droplets of foreign material and foreign body giant cell reaction consistent with contents of ruptured medical device", without evidence of…
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Medical study · Medical research · 2021
Mesothelin-targeted CAR-T cell therapy for solid tumors
…15. In the first trial in humans, one mesothelioma patient had a severe allergic reaction (anaphylaxis). A Memorial Sloan Kettering conference abstract reported results for 19 pleural mesothelioma patients given the cells into the chest. Of…
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Medical study · Medical research · 2020
Unusually favorable outcome of 6 consecutive patients with diffuse malignant peritoneal mesothelioma treated with repeated doses of intraperitoneal paclitaxel. A case series
…died of disease 15 years after treatment. Three of the 6 had a grade III/IV adverse event: an inverted and then infected port, an intense allergic reaction, and a small bowel perforation. In 5 patients…
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Medical study · Medical research · 2022
Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial
…193a-5p, also appeared in earlier mesothelioma data. Of 21 men who took AWPC, 11 reported at least one adverse reaction. None were considered serious. AWPC was suspected as the cause in 3 men, all of…
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Medical study · Medical research · 2020
Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (Chlorocebus aethiops)
…records showed no history of radiation. The authors concluded that this was a benign reactive mesothelial hyperplasia, a reaction to inflammation of the body linings (polyserositis), that mimicked an epithelioid mesothelioma. They stated that the cause…
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Medical study · Medical research · 2022
Radiological Findings in the Case Exposed to Zirconium
…a result of a tissue reaction that occurs with the accumulation of inorganic particles. Pathoclinical features may vary depending on the type of inhaled particle. Today, fibrotic and nonfibrotic tissue reactions are well defined in some…
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Medical study · Medical research · 2021
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles
…epidemiological and animal studies have demonstrated that excess iron is a risk for cancer. The responsible mechanisms are: 1) increased intracellular iron catalyzes the Fenton reaction to generate hydroxyl radicals, leading to mutagenic oxidative DNA lesions…
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Medical study · Medical research · 2021
MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck
…mice four times weekly. We extracted total RNA from lung tissues and performed microarray analysis for miRNA and gene expression. We also carried out real-time polymerase chain reaction (PCR), Western blotting, and immunohistochemistry to confirm…
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Medical study · Medical research · 2021
Osteopontin mRNA expression by rat mesothelial cells exposed to multi-walled carbon nanotubes as a potential biomarker of chronic neoplastic transformation in vitro
…were used as a positive control. Osteopontin (OPN) mRNA was assayed as a biomarker of transformation by real time quantitative polymerase chain reaction (qPCR) and transformation was determined by a cell invasion assay. Exposure to rMWCNTs…
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Medical study · Medical research · 2020
Targeting ROR1 in combination with pemetrexed in malignant mesothelioma cells
…Microarray, quantitative polymerase chain reaction, and Western blot analyses showed that there were differences in the suppression of mRNA and proteins between H2452 and H28 cells transfected with siROR1 compared with those transfected with control siRNA…
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Medical study · Medical research · 2021
UHRF1 Is a Novel Druggable Epigenetic Target in Malignant Pleural Mesothelioma
…in malignant pleural mesothelioma (MPM). This study was undertaken to explore the therapeutic potential of targeting UHRF1 in MPM. Microarray, real-time quantitative reverse transcription-polymerase chain reaction, immunoblot, and immunohistochemistry techniques were used to evaluate…
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Medical study · Medical research · 2020
LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma
…that could act as MPM biomarkers. We carried out additional molecular analyses of these potential markers using MPM patient tissue samples via quantitative polymerase chain reaction. We identified Lysyl oxidase (LOX), Lysyl oxidase homologs 1&2…
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Medical study · Medical research · 2024
Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases
…length was also determined in samples from MM patients before and after chemotherapy. Telomere length was determined by monochromatic multiplex quantitative polymerase chain reaction (PCR), while competitive allele-specific PCR was used to genotype hTERT rs10069690…
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Medical study · Medical research · 2021
Re-evaluating the pathogenicity of the c.783+2T>C BAP1 germline variant
…None of the three available tumors showed an allelic loss, there was no discernable effect on alternative splicing based on reverse-transcription polymerase chain reaction, and there was no decrease or loss of somatic protein expression…
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Medical study · Medical research · 2020
Attenuation of oxidative stress and chromosomal aberrations in cultured macrophages and pulmonary cells following self-sustained high temperature synthesis of asbestos
…However, there was an attenuation of redox status imbalance and an absence of chromosomal aberrations, which probably reflects the loss of the asbestos fibrous structure following SHS reaction, as demonstrated by electron microscopy analyses. In conclusions…