5 results for “Reaction Department”
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Medical study · Medical research · 1992
Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]
…in concentrations varying from 0 to 250 mM. Inclusion of deferoxamine in the reaction mixture provided similar results of diminishing both TBA reactive products and dihydroxybenzoic acid generation. We conclude that oxidant generation by crocidolite is…
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Medical study · Medical research · 1989
Dusts causing pneumoconiosis generate .OH and produce hemolysis by acting as Fenton catalysts
…were studied. The authors tested whether dusts act as Fenton catalysts, turning hydrogen peroxide into damaging hydroxyl radicals, a reaction in which iron or other metals take part. With ascorbate (vitamin C) present, amosite, chrysotile and…
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Medical study · Medical research · 1998
Antiradical and chelating effects in flavonoid protection against silica-induced cell injury
Quercetin, dihydroquercetin, and rutin are capable of scavenging superoxide anion (rate constants of the reaction with superoxide at pH 10 were 1.7 x 10(5), 1.5 x 10(5), and 0.5 x 10…
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Medical study · Medical research · 1984
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
…hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos…
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Medical study · Medical research · 1989
Tobacco-borne siderophoric activity
…Indeed, elements in tobacco smoke and asbestos synergistically damage DNA through reactions mediated by the (probably iron-dependent) formation of hydroxyl radical. These considerations prompted the hypothesis that tobacco smoke might contain substances capable of "delocalizing…