2 results for “Reaction Department”
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Medical study · Medical research · 2016
Population pharmacokinetics and exposure-response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection
…models. Amatuximab PK was best described by a two-compartment model with parallel linear and nonlinear elimination pathways. Body weight and an antidrug antibodies reaction with the titer >64 affected volume of distribution and clearance, respectively…
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Medical study · Medical research · 2001
Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma
…Coupled with this, we have previously noted a common serological reaction to the beta isoform of topoisomerase II, suggesting that it may be aberrantly expressed in patients with mesothelioma. We assessed the expression of topoisomerase II…