30 results for “Reaction Department”, page 1 of 2
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Medical study · Medical research · 1983
Reaction of mineral dusts with primary lung fibroblast cultures
This laboratory study, which also reviewed the authors' earlier work, tested nine mineral dusts on rabbit lung fibroblast cultures (collagen-making cells). Single doses of 10 to 1000 µg per culture were added on day 3. DNA and cell-layer collagen…
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Medical study · Medical research · 1974
The ingestion of asbestos fibers
…which probably came from iron-containing macrophages. It is suggested that pleural plaques and hyaline nodules in the peritoneum represent a hypersensitivity reaction to ferritin protein coating on asbestos fibers. In South Africa only a few…
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Medical study · Medical research · 2002
Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates
…NR8383). Our objective was to quantitatively determine the biological response upon interaction of the test particulates/fibers with lung macrophages and to evaluate the efficacy of surface iron on the zeolites to promote the Fenton reaction…
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Medical study · Medical research · 1984
Pulmonary toxicology of silica, coal and asbestos
…the air sacs and fibrotic nodules failed to develop. The author argued that the simple lung lesion of coal workers is best seen as a nonspecific reaction to heavy dust accumulation. In red-blood-cell tests…
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Medical study · Medical research · 1983
Transmigration of ingested asbestos
…with crystals resembling amosite visible inside cells. Saline injected into two control rats caused a smaller reaction. Rats given 100 mg of amosite by stomach tube daily for 5 days showed no macrophage response or other…
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Medical study · Medical research · 1974
Lymphohematogenous spread of asbestos
…kidney, brain and other organs, and of what damage they cause. The author concluded that knowing the injury reaction and tissue dose-response would help determine how much asbestos, and what kind, if any, humans can…
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Medical study · Medical research · 1974
Response of cell cultures to asbestos fibers
The reaction of macrophages to asbestos and glass fibers was studied by light and by electron microscopy. Measurements were made of LDH release, staining with erythrosine B, and lactate production. Size and shape of asbestos fibers…
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Medical study · Medical research · 2016
Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases
…glycogen synthase kinase-3β (GSK-3β), and Akt were performed to confirm their involvement in asbestos-induced EMT. Real-time polymerase chain reaction (PCR), Western blotting, and gelatin zymography were performed to detect mRNA…
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Medical study · Medical research · 1983
Effects of chrysotile on a lysosomal enzyme preparation and on the hydrolytic enzyme activity of cultured alveolar macrophages
…inhibit or enhance lysosomal enzyme activity at either pH but may preferentially absorb specific enzymes and that the binding reaction between any given enzyme and mineral can be dependent on the presence of other organic compounds…
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Medical study · Medical research · 1983
Interactions of chrysotile asbestos with erythrocyte membranes
…cells and bind to cell membranes which may become wrapped around the fibers. This reaction is prevented by pretreatment of the cells with neuraminidase. The distribution of lectins which bind to membrane glycoproteins is altered by…
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Medical study · Medical research · 1983
Effect of intrabronchially instilled amosite on lavagable lung and pleural cells
…the study. No pleural reaction was seen in the saline instilled group. The inflammatory reactions indicated by the composition of the lavaged cells of the lung represent the in vivo toxicity of intrabronchially instilled amosite. The…
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Medical study · Medical research · 1974
Correlation between the tissue response and asbestos fiber content
…and here secondary factors may be concerned. Electron microscopy suggests that optically visible fibers constitute a reasonably constant proportion of the total irrespective of the pathological reaction. Light microscopy may thus afford a guide to the…
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Medical study · Medical research · 1998
Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants
…RNA was extracted, reverse transcribed, and amplified by polymerase chain reaction with degenerate primers to visualize alterations in gene expression. The seven clones obtained were sequenced and encoded the mitochondrial genes, NADH dehydrogenase subunits ND5 and…
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Medical study · Medical research · 1994
An experimental approach to the evaluation of the biopersistence of respirable synthetic fibers and minerals
…initial evaluation of solubility and durability, they cannot simulate the dynamics of inhalation deposition and clearance and the subsequent systemic reaction to fibers and minerals that occurs in the animal. To evaluate the biopersistence of synthetic…
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Medical study · Medical research · 1983
Effect of asbestos on the metabolism of vasoactive substances in isolated perfused guinea pig lungs
…The tissue response consisted of both inflammatory reaction of terminal and respiratory bronchioles and diffuse alveolar septal infiltration with interstitial fibrosis. The reaction was characterized at six months by a progressive bronchiolitis obliterans with fibroblastic proliferation…
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Medical study · Medical research · 1997
Pleural macrophage recruitment and activation in asbestos-induced pleural injury
…by scanning electron microscopy. Pleural macrophage supernatants were assayed for production of nitric oxide (NO) (by the Griess reaction) and tumor necrosis factor alpha (TNF-alpha) (by an enzyme-linked immunosorbent assay method). Significantly greater amounts…
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Medical study · Medical research · 1997
Short-term inhalation and in vitro tests as predictors of fiber pathogenicity
…and SiC. However, measurements of BrdU uptake into lung cells showed that amosite and SiC produced a greater reaction than code 100/475, which itself caused no more proliferation than that seen in untreated lungs. These…
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Medical study · Medical research · 1998
Contribution of reactive oxygen and nitrogen species to particulate-induced lung injury
…reactive oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical formed through Fenton/Haber-Weiss reactions) and of reactive nitrogen species, in which nitric oxide reacts with superoxide to form peroxynitrite, an oxidant that nitrates tyrosine residues…
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Medical study · Medical research · 1974
Biological effects of ingested asbestos: report and commentary
…fibers in water, food and drugs, gut-wall passage, and tissue reactions. For example, Nicholson reported 20 to 70 million amphibole fibers per liter in Duluth's drinking water. The author judged there was little doubt…
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Medical study · Medical research · 1998
Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis
…caused lung immune cells to release an inflammatory signaling protein (TNF-alpha), which the authors linked to metal-driven free radical reactions. The authors concluded that their studies support the hypothesis that ROS are involved in…