19 results for “Reaction Department”
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Medical study · Medical research · 1983
Acute lung response to amosite asbestos: a morphological study
This was an animal experiment in guinea pigs. It examined the lung's reaction during the week after amosite asbestos was placed in the windpipe. Exposed animals received 17.5 mg of ground commercial-grade amosite…
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Medical study · Medical research · 1974
Inhalation carcinogenesis from various forms of asbestos
…amosite). A fibrogenic response to these dusts was observed in all five animal species, the severity corresponding to the extent of exposure (with reaction to chrysotile frequently very slight). Gerbils developed frequent alveolar proteinosis. Mice developed…
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Medical study · Medical research · 1967
Tissue response to intraperitoneal asbestos with preliminary report of acute toxicity of heart-treated asbestos in mice
…plaques and invasive granulomas, while none of 12 talc mice did. The authors described the reaction as histologically similar to mesothelioma but obtained no morphologic evidence of actual malignancy. In a second experiment, asbestos heated to…
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Medical study · Medical research · 1993
Activation of UICC crocidolite: the effect of conversion of some ferric ions to ferrous ions
…The amount of iron in asbestos fibers, its oxidation state, and its availability to specific chelating agents determine their ability to catalyze the aforementioned reactions. In the present study, the activation of UICC crocidolite was achieved…
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Medical study · Medical research · 1987
Crocidolite-induced lipid peroxidation in rat lung microsomes. I. Role of different ions
…in rat lung microsomes both from rats pretreated with 3-methylcholanthrene and from untreated controls. This increase was dependent on the concentration of these ions in the reaction mixture. Crocidolite alone increased peroxidation in microsomal fractions…
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Medical study · Medical research · 1997
Cellular mechanisms of reactive oxygen metabolite generation from human polymorphonuclear leukocytes induced by crocidolite asbestos
…an enhancement. We conclude that crocidolite-induced ROM generation involves a cell surface reaction due to influx of extracellular calcium through calcium channels and the activation of NADPH oxidase on the PMN cell membrane. This hypothesis…
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Medical study · Medical research · 1986
Studies on surface properties of asbestos. II. Role of dimensional characteristics and surface properties of mineral fibers in the induction of pleural tumors
…mineral and therefore the nature of active surface sites, and the aspect ratio of the particle. These two parameters can intervene in a mechanism of model reaction involving the basic properties of lateral faces of fibers.
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Medical study · Medical research · 2002
Chemiluminescent detection of induced reactive oxygen metabolite production of human polymorphonuclear leucocytes by anthophyllite asbestos
…tyrosine kinase, which resides in the pathway to cause PMN activation. The strong ROM reaction of PMN by anthophyllite suggests that the surface characteristics of the fiber may participate in the pathogenic mechanisms of anthophyllite asbestos.
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Medical study · Medical research · 1978
The adsorption of biological macromolecules by mineral dusts
…strong” adsorption reactions were noted with serum proteins, the latter being considered as the most specific for each mineral and perhaps the most important physiologically. The implications of the observed adsorption phenomena to the reaction between…
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Medical study · Medical research · 1985
An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats
…structure, and surface charge, the lung tissue reaction differed considerably. Lungs of animals exposed to UICC chrysotile B showed significant pathological alterations as early as 7 days following treatment. The lesions were localized in and around…
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Medical study · Medical research · 1973
Experimental infective pneumoconiosis: effect of asbestos dust and Candida albicans infection on the lungs of rhesus monkeys
…albicans infection alone caused acute inflammatory reaction in the early stages while at the termination of experiment (330 days) the only evidence of pulmonary candidiasis was a few small fibrotic foci of compactly arranged reticulin fibers…
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Medical study · Medical research · 1989
Rat lung reactivity to natural and man-made fibrous silicates following short-term exposure
…more significantly to attapulgite and Fiberfrax although the tissue reaction differed considerably for these two materials. While attapulgite, at doses up to 10 mg caused minimal reactions characterized by mononuclear cell infiltration mainly in the alveolar…
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Medical study · Medical research · 1987
The lung biological activity of American attapulgite
…not an inert material for lung tissue; it does produce a macrophagic and neutrophilic alveolitis in the early inflammatory phase of lung reaction with peribronchiolar involvement in some sheep. Whether or not this initial attapulgite induced…
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Medical study · Medical research · 1987
Prevention of asbestos-induced cell death in rat lung fibroblasts and alveolar macrophages by scavengers of active oxygen species
…active oxygen species. In this regard, the iron associated with the fiber and/or its interaction with cell membranes might be critical in driving a modified Haber-Weiss (Fenton-type) reaction resulting in production of OH(.).
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Medical study · Medical research · 1985
Selective exposure and analysis of the sheep tracheal lobe as a model for toxicological studies of respirable particles
…at Day 1) and only macrophages after; lung histology documented an early macrophagic alveolitis which decreased to less than 10% of the initial inflammatory reaction at Day 60, without other distortion of the lung and airway…
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Medical study · Medical research · 1986
Outcome of asbestos exposure (lung fibrosis and antinuclear antibodies) with respect to skin reactivity: an 8-year longitudinal study
…Among the 52 men who did respond, 2 did. Workers with ANA more often had weak skin reactions, and this was only partly explained by asbestosis cases. Smoking habits did not differ between responders and nonresponders…
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Medical study · Medical research · 1985
Asbestos-induced decomposition of hydrogen peroxide
…radicals in this process was delineated employing the OH radical scavenger dimethyl sulfoxide (DMSO). A mechanism involving the Fenton and Haber-Weiss reactions as the pathway for the H2O2 decomposition and OH radical production is postulated.
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Medical study · Medical research · 1981
Manifestations of cellular immunity in the rat after prolonged asbestos inhalation. II. Alveolar macrophage-induced splenic lymphocyte proliferation
…some respects, to the lymphoproliferative response evoked by sodium periodate-treated control macrophages, since both these reactions peaked at 72 hr and were abolished by treatment of the macrophages with the reducing agent, L-cysteine. This…
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Medical study · Medical research · 1981
Comparative pulmonary responses to inhaled inorganic fibers with asbestos and fiberglass
…rats and hamsters but not in guinea pigs. Fine fiberglass particles were not fibrogenic. Rats revealed more fibrogenic pulmonary reactions than guinea pigs or hamsters. A few pulmonary tumors developed in animals exposed to asbestos, Fybex…