2 results for “Reaction Department”
-
Medical study · Medical research · 2003
Asbestos bodies: clues to the mechanism of asbestos toxicity?
…lung, ascorbate was oxidized to oxalate in the presence of H2O2, a reaction inhibited by the iron chelator deferoxamine. The author called this a novel mechanism that may contribute to the pathogenicity of asbestos fibers. Oxidation…
-
Medical study · Medical research · 2003
Oxalate deposition on asbestos bodies
…vitro generated approximately 42 nmol of oxalate in 24 hours. Oxalate generation was diminished significantly by the inclusion of either deferoxamine or dimethylthiourea in the reaction mixture. Incubation of asbestos bodies and uncoated fibers isolated from…