14 results for “General Electric”
-
Medical study · Medical research · 2010
Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets
…explain resistance against immunological therapies. Gene expression features found in other resistant cancer types related to DNA repair and replication are shared by mesothelioma and could represent general features of tumour resistance. Targeted suppression of some…
-
Medical study · Medical research · 2012
Mesothelioma and lung cancer mortality: a historical cohort study among asbestosis workers in Hong Kong
…all 124 men newly diagnosed with asbestosis at Hong Kong's Pneumoconiosis Clinic between 1981 and 2008 until the end of 2008. Deaths were compared with male general population rates. Most worked in shipyards or construction…
-
Medical study · Medical research · 2013
A genome-wide association study for malignant mesothelioma risk
This genome-wide association study looked for inherited DNA variants (SNPs) linked to malignant mesothelioma risk. The authors compared 428 mesothelioma patients from Western Australia and Queensland with 1269 general-population controls from Busselton, Western Australia…
-
Medical study · Medical research · 2004
Asbestos: a clear and present danger--a UK perspective
…heard the appeals in May 2002 and reversed that decision. The author wrote that a UK mesothelioma victim might receive £40k to 50k in general damages for pain and suffering, plus care costs and financial losses…
-
Medical study · Medical research · 2010
Impact of malignant mesothelioma in Taiwan: a 27-year review of population-based cancer registry data
…7.6 for males and 13.5 for females. Compared with the age- and sex-matched general population, the authors estimated 14.2 expected years of life lost per case (95% confidence interval 12.8 to…
-
Medical study · Medical research · 2011
Pemetrexed re-challenge in pleural malignant mesothelioma: an option for a subset of patients initially treated with pemetrexed-platinum doublets in the first-line setting?
…results as background. As the editorial described it, the Ceresoli study included 32 patients in good general condition whose disease had not progressed for at least 3 months after first-line treatment. On re-treatment, 19%…
-
Medical study · Medical research · 2019
Survival in patients with malignant pleural effusion undergoing talc pleurodesis
…to 2.39; 222 trial patients). The authors concluded there is an association between successful pleurodesis and survival. They called the results by no means definitive and had no data on patients' general fitness (performance status).
-
Medical study · Medical research · 2018
Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma
…of liver, kidney, heart or muscle toxicity. The authors called their patient data preliminary. With few patients and no comparison group given other treatments, they could not tell general prognosis apart from prediction of cisplatin response.
-
Medical study · Medical research · 2015
Treatment patterns and survival analysis in 9014 patients with malignant pleural mesothelioma from Belgium, the Netherlands and England
…this difference is probably overrated because of selection bias. They noted that treatment definitions differed between countries and that data on other illnesses and general fitness were missing. The authors concluded that chemotherapy has become standard…
-
Medical study · Medical research · 2005
Transcriptional profiling of mesothelioma using microarrays
…lacking. Large-scale transcriptional profiling using microarrays is frequently a part of studies to explore gene expression patterns in cancer and other diseases. In general, microarray based experiments can facilitate the identification of tumor molecular markers…
-
Medical study · Medical research · 2020
The Current Understanding Of Asbestos-Induced Epigenetic Changes Associated With Lung Cancer
…epigenetic changes from those due to non-asbestos causes of lung cancer. Asbestos-associated lung cancers exhibit less methylation variability than lung cancers in general, and in a large proportion of samples variability has been found…
-
Medical study · Medical research · 2004
Pathological anatomy and molecular pathology
…A reliable pathological diagnosis is the basis for therapeutic, prognostic, and medicolegal consequences. In general, it can be achieved by thoracoscopic inspection with specifically directed biopsy. Furthermore, a description of the peculiarities of each mesothelioma by…
-
Medical study · Medical research · 2013
Potential toxicity and safety evaluation of nanomaterials for the respiratory system and lung cancer
…regarding chronic exposure at low doses is more complicated. The long-term accumulation of ENPs in the respiratory system cannot be excluded. However, at present, exposure data for the general public regarding ENPs are not available.
-
Medical study · Medical research · 2017
Need for randomized clinical trials testing targeted therapies in malignant pleural mesothelioma
This was a letter to the editor of Lung Cancer, written in response to an earlier article on BAP1 as a treatment target. In it, the authors reported a small meta-analysis, which pools the results of published trials, of targeted drug therapies for…