4 results for “Reaction Department”
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Medical study · Medical research · 1984
Fiber localization and its relationship to lung reaction in rats after chronic inhalation of chrysotile asbestos
…with histologic changes indicating marked epithelial injury. Increased amounts of fibers are also localized in the lung interstitium with continued exposure to asbestos and are associated with a progressive interstitial fibrotic reaction. Following cessation of exposure…
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Medical study · Medical research · 1988
Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos
…this would be the most likely site of a significant cellular or fibrotic reaction. The characteristics and progression of tissue reactions occurring at first alveolar duct bifurcations after a single brief asbestos exposure was defined using…
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Medical study · Medical research · 1983
A murine model of asbestosis
…an initial macrophage reaction was found to progress to "asbestos body" formation and diffuse focal interstitial fibrosis within 1 year of a chronic exposure period. This reaction was most intense in areas adjacent to respiratory bronchioles…
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Medical study · Medical research · 2007
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice
…decreased in PKCdelta-/- mice. At 9 days, microarray and quantitative reverse transcriptase-polymerase chain reaction analysis of lung tissues revealed increased mRNA levels of the profibrotic cytokine, IL-4, in asbestos-exposed wild-type mice but…