10 results for “Reaction Department”
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Medical study · Medical research · 1990
Pulmonary reaction to long and short asbestos fibers is independent of fibroblast growth factor production by alveolar macrophages
This rat study asked whether alveolar macrophage secretions (scavenger cells in the lung's air spaces) explain why long, but not short, crocidolite fibers cause lung fibrosis. UICC crocidolite was separated into long fibers (mean 24.4 microns) and…
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Medical study · Medical research · 1984
Fiber localization and its relationship to lung reaction in rats after chronic inhalation of chrysotile asbestos
…with histologic changes indicating marked epithelial injury. Increased amounts of fibers are also localized in the lung interstitium with continued exposure to asbestos and are associated with a progressive interstitial fibrotic reaction. Following cessation of exposure…
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Medical study · Medical research · 1988
Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos
…this would be the most likely site of a significant cellular or fibrotic reaction. The characteristics and progression of tissue reactions occurring at first alveolar duct bifurcations after a single brief asbestos exposure was defined using…
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Medical study · Medical research · 1985
Pathologic changes in the small airways of the guinea pig after amosite asbestos exposure
… where these fibers penetrated the airway walls, an interstitial inflammatory and fibrotic reaction (asbestosis) occurred. It is concluded that 1) amosite asbestos produces diffuse abnormalities throughout the noncartilagenous airways and possibly the cartilagenous airways as well…
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Medical study · Medical research · 1983
A murine model of asbestosis
…an initial macrophage reaction was found to progress to "asbestos body" formation and diffuse focal interstitial fibrosis within 1 year of a chronic exposure period. This reaction was most intense in areas adjacent to respiratory bronchioles…
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Medical study · Medical research · 1986
Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis
…proliferation, and collagen deposition. To evaluate the potential involvement of alveolar macrophages in the subsequent fibrogenic reaction, the authors studied the effects of macrophages from normal and asbestos-treated rats upon lung fibroblast proliferation in vitro…
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Medical study · Medical research · 2007
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice
…decreased in PKCdelta-/- mice. At 9 days, microarray and quantitative reverse transcriptase-polymerase chain reaction analysis of lung tissues revealed increased mRNA levels of the profibrotic cytokine, IL-4, in asbestos-exposed wild-type mice but…
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Medical study · Medical research · 2005
Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling
…normal and tumor tissues, and tumors with different morphologies. Microarray gene expression data were confirmed using quantitative reverse transcriptase-polymerase chain reaction and protein analysis for three novel candidate oncogenes (NME2, CRI1, and PDGFC) and one…
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Medical study · Medical research · 1991
Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis
Alveolar macrophages (AM) and their production of interleukin-1-like activity (IL-1) and macrophage-derived growth factor for fibroblasts (MDGF) were examined during chronic inflammatory reactions leading to either granuloma formation or fibrosis. Groups of…
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Medical study · Medical research · 1973
Acute and chronic effects of intraperitoneal injection of two types of asbestos in rats with a study of the histopathogenesis and ultrastructure of resulting mesotheliomas
…approximately 40% mortality, within 8 days after the injection associated with acute peritonities. Tissue reactions to these two types of asbestos were significantly different. Crocidolite fibers were easily seen by light microscopy, in the tissue sections…