37 results for “Owens-Illinois”, page 2 of 2
-
Medical study · Medical research · 1971
Asbestos exposure to coke oven operators
…not necessarily with benzpyrene. They offered another explanation. Coke ovens and gas retorts require effective insulation, much of it containing asbestos, and the authors had been informed that its repair and maintenance were often the responsibility…
-
Medical study · Medical research · 2019
Refining classification of malignant pleural mesothelioma reveals its Achilles' heel
…gene-activity results were checked against protein levels in a replication series. The author concluded that the present classification cannot predict the most effective treatments and that the study opens a window for new targeted treatments.
-
Medical study · Medical research · 2011
Ban asbestos phenomenon: the winds of change
The shift in the public perception of asbestos from "magic mineral" to "deadly dust" owes much to the mobilization by asbestos victims, ban-asbestos activists, health and safety campaigners, and individuals concerned about the global asbestos…
-
Medical study · Medical research · 2012
Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: shedding light on fiber entry mechanism
The emergence of nanotechnology represents an important milestone, as it opens the way to a broad spectrum of applications for nanomaterials in the fields of engineering, industry and medicine. One example of nanomaterials that have the…
-
Medical study · Medical research · 2020
Induction of Gamma-Glutamyltransferase Activity and Consequent Pro-oxidant Reactions in Human Macrophages Exposed to Crocidolite Asbestos
Asbestos is the main causative agent of malignant pleural mesothelioma. The variety known as crocidolite (blue asbestos) owns the highest pathogenic potential, due to the dimensions of its fibers as well as to its content of…
-
Medical study · Medical research · 1987
Microwave polymerisation of epoxy resin: rapid processing technique in ultrastructural pathology
…authors tested whether microwave irradiation could polymerise epoxy resin when preparing tissue for electron microscopy. With conventional ovens this step needs at least half an hour. The work was done at the University Department of Pathology…
-
Medical study · Medical research · 2021
Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
…of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.
-
Medical study · Medical research · 2020
Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody-Drug Conjugate
…increased binding of AM1 to EGFR-positive tumor cells, opens the possibility to target a wide array of tumors beyond those with high levels of EGFR overexpression or amplification, including those insensitive to auristatin-based ADCs…
-
Medical study · Medical research · 2009
Molecular targets in malignant pleural mesothelioma treatment
…inhibitors like bevacizumab, are among the most promising agents under evaluation in clinical trials. Mesothelioma is a malignancy which owes its chemoresistance to an apoptotic defect. Thus the introduction of new biologic drugs like vorinostat, bortezomib…
-
Medical study · Medical research · 1976
Open-cast technique for metal molds used in constructing facial prostheses
…Lino-type metal which is very heavy. However, this has not restricted the use of this technique since these metals cast well and can be easily placed in large ovens. This technique, because of its advantages…
-
Medical study · Medical research · 2021
Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques
…Fe content in the ABs was higher than that possibly contained in chrysotile and crocidolite. This finding opens two opposite scenarios, the first with Fe coming from the fiber bulk and concentrating on the surface as…
-
Medical study · Medical research · 2020
A new trajectory approach for investigating the association between an environmental or occupational exposure over lifetime and the risk of chronic disease: Application to smoking, asbestos, and lung cancer
…dose and the timing of exposure. The proposed approach opens new perspectives for the analyses of dose-time-response relationships between protracted exposures and the risk of developing a chronic disease, by providing a complete picture…
-
Medical study · Medical research · 2019
Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study
…is more effective than Pe alone in inhibiting MPM cell line malignant phenotype. The innovative use of specifically targeted GNPs opens the perspective of local intrapleural administration to avoid normal cell toxicity and enhance chemotherapy efficacy.
-
Medical study · Medical research · 2021
Pathological Characterization of Tumor Immune Microenvironment (TIME) in Malignant Pleural Mesothelioma
…a greater understanding of the pathogenetic mechanisms in tumor development and pathobiology of TIME, that opens the way to new therapeutic strategies. The study of TIME is fundamental in identifying appropriate prognostic and predictive tissue biomarkers…
-
Medical study · Medical research · 2018
Tumor-specific genetic variants can be detected in circulating cell-free DNA of malignant pleural mesothelioma patients
…time the presence of ctDNA within circulating DNA of treatment naïve MPM patients. This finding opens perspectives towards the use of ctDNA as a biomarker for (early and differential) diagnosis, treatment and treatment monitoring of MPM…
-
Medical study · Medical research · 2020
Inhibitors of cytoskeletal dynamics in malignant mesothelioma
…species. One of these, imipramine blue, was particularly effective in counteracting some key malignant properties of highly invasive MM cells. This opens a new possibility for targeted inhibition of MMs based on well-established molecular mechanisms.
-
Medical study · Medical research · 2001
Human T cell responses to endogenously presented HLA-A*0201 restricted peptides of Simian virus 40 large T antigen
…of SV40 specific human cytotoxic T lymphocytes that recognize endogenously processed peptides from SV40. This peptide identification study opens the possibility to investigate immune responses against SV40 in mesothelioma patients and in individuals exposed to SV40.